2012 Nsp Week 8 Pharm

Front 1

Morphine

Back 1

OpioidHigh MOR affinity, Low KOR-DOR affinitySevere painvasodilation, bronchoconstriction, histamine release

Front 2

Levorphanol

Back 2

OpioidHigh MOR affinity, Low KOR-DOR affinitySevere painLike Morphine, Less N/V than morphine

Front 3

Meperidine

Back 3

OpioidHigh MOR affinity, Low KOR-DOR affinitySevere pain, strong analgesicTemors, SeizuresOnly parenterally

Front 4

Diphenoxylate

Back 4

Opioid - Meperidine AnalogHigh MOR affinity, Low KOR-DOR affinityDiarrhea

Front 5

Loperamide

Back 5

Opioid - Meperidine AnalogHigh MOR affinity, Low KOR-DOR affinityDiarrhea

Front 6

Fentanyl

Back 6

OpioidHigh MOR affinityLipid solubile (fat), Rapid Onset, Anestheisa adjunct100x more potent than morphineTransdermal patch

Front 7

Sufentanil

Back 7

Opioid - Fentanyl analogHigh MOR affinity, KOR-DOR affinity5x more potent than FentanylParenterally

Front 8

Remifentanil

Back 8

Opioid - Fentanyl analogHigh MOR affinityRapid onset, Short half-life, Short procedures1/2 potency of FentanylIV, not for post op

Front 9

Methadone

Back 9

Synethic opioidMOR against, NMDA blocker, MA reuptake blockerRehab, Cancer-neuropathic painOral

Front 10

Codeine

Back 10

Partial agonistPartial MOR Agonist Used in combo with NSAIDS

Front 11

Buprenorphine

Back 11

Mixed Ago-AntaPartial MOR Agonist, KOR antagonist Long acting, Rehab, Sublingually

Front 12

Pentazocine

Back 12

Mixed Ago-AntaKOR Agonist, weak MOR antagonistMorphine Rehab, Respiratory depression ceilingDysphorira, PsychomemeticOral

Front 13

Nalbuphine

Back 13

Mixed Ago-AntaStrong KOR agonist, Strong MOR antagonistMorphine Rehab, Respiratory depression ceilingdysphorira, body image distortionsParenterally

Front 14

Butorphanol

Back 14

Mixed Ago-AntaKOR Agonist, weak MOR antagonistIntranasal

Front 15

Tramadol

Back 15

Weak MOR, Weak NE, Weak SNRISeizures, NOT to use with SSRI-MAOI

Front 16

Dextromethorphan

Back 16

NMDA blocker at high doseCough suppression

Front 17

Naloxone

Back 17

AntagonistHigh MOR affinity, Low KOR-DOR affinityReverse Opioid overdose, fast action durationIV

Front 18

Naltrexone

Back 18

AntagonistnaloxoneAlcohol addiction, longer duration

Front 19

Methylnaltrexone

Back 19

Does cross BBBPrevent constipation

Front 20

Nitrous Oxide

Back 20

Anesthetic - InhaledExcellent analgesic, weak anesthetic, enhance GABA to increase Cl-Must be mixed, rapid onset, rapid recoveryPressure increase in cavities - pneumothorax, obstructed middle ear etc.., post op n/vInhaled

Front 21

Isoflurane

Back 21

Anesthetic - Inhaledenhance GABA to increase Cl-rapid onset, rapid recovery, maintenance anestheticDecrease BP via dilates art., smooth muscle relax, no labor and deliveryPungent odor so admin after induction phase, inhaled,

Front 22

Desflurane

Back 22

Anesthetic - Inhaledenhance GABA to increase Cl-rapid onset, rapid recovery, maintenance anestheticIncrease BP, ventilation decrease @ >1 MAC, increase intracranial pressureAdmin after induction due to airway irriatation

Front 23

Sevoflurane

Back 23

Anesthetic - Inhaledenhance GABA to increase Cl-rapid onset, rapid recovery, outpatient CO not Maintained, Reacts (nephrotoxic) with CO2 absorbents so need special equipmentInhaled

Front 24

Halothane

Back 24

Anesthetic - Inhaledenhance GABA to increase Cl-Anesthesia induction, Slow induction, fat soluble so slow recoveryDecrease BP via decrease CO, smooth muscle relax, no labor and delivery, decrease CO, Hepatic necrosis via trifluroacetic acids, Malignant HyperthermiaInhaled

Front 25

Sodium Thiopental

Back 25

Anesthetic - IVpotentiates GABA to increase Cl-Anestheisa induction, short duration, fat soluble, patients with cerebral swellingDecrease BP via decrease COIV

Front 26

Propofol

Back 26

Anesthetic - IVpotentiates GABA to increase Cl-Anestheisa induction and mainenance, rapid onset, shorter recovery than thiopental, antiemetic for n/v risk patientsDecrease BP via decrease CO and peripheral vasodilation, injection painIV

Front 27

Etomidate

Back 27

Anesthetic - IVpotentiates GABA to increase Cl-Induction for Cardo Disease patients, rapid onset, rapid recovery, no anagesic propertyInjection pain, myoclonic movements, Hypotension via adrenocortical suppressionIV

Front 28

Ketamine

Back 28

Anesthetic - IVInhibits glutamate NMDA receptorsInduction and maintenance, dissociative anesthesia, also AnalgesicPatients move around, Increase BP and CO, increase intracranial pressure, HallucinationsIV

Front 29

Midazolam

Back 29

BenzidiazepineSedation, Amnesia prior to induction, rapid onset, short durationIV

Front 30

Dexmedetomidine

Back 30

a2-adrenergic agonistSedation, Analgesic with min RR depressionHypotension, Bradycardia