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31 Cards in this Set
- Front
- Back
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What is hodgkins lymphoma?
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often above the diaphram and localized
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what is the staging of hodgkins lymphoma?
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I - Localized
II - local spread, one side of diaphram III - regional lymph node spread (both sides of diaphram IV - metastatic |
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what does the A and B mean in lymphoma staging?
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A = asymptomatic
B = > 10% weight loss, profuse night sweats, high fevers |
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What is the treatment of IA, IB, IIA, IIB hodgekins lymphomas?
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radiation therapy if local based on laparotomy
but most commonly chemo and RT |
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treatment for IIIA hodgkins lymphomas?
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usually chemo (+/-) RT
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treatment for IIIB, IVA or IVB hodgkins lymphomas?
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chemo
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treatment if any have bulky disease in hodgkins lymphomas?
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combined modality chemo and RT
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When is surgury used for hodgkins lymphomas?
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rarely used since lymphomas usually respond well to chemo and RT
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What is done for relapse in hodgkins lymphomas?
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if only RT used then use chemo
if chemo used and late relapse (>12 months) more chemo or autologous HSCT if chemo used and early relapse (<12 months) autologous HSCT |
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what is the location of nonhodgkins lymphomas?
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more often below the diaphram, and disseminated
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what is the staging of hodgkins disease?
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not as important
Limited (stages I, II) Advanced (III, IV, IIX) |
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What regimines are used for nonhodgkins lymphomas?
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MOPP, ABVD, hybrids (MOPP/ABVD), BEACOPP
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what does MOPP stand for?
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mechlorethamine, vincristine, prednisone, probarbazine
more sterility and secondary AML |
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what does ABVD stand for?
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doxorubicin, bleomycin, vinblastine, dacarbazine
less sterilaty and secondary AML |
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BEACOPP?
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bleomycin, etopside, doxorubicin, cyclophosphamide, vincristine, procarbazine
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What is the adverse rxn of procarbazine?
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can cause disulfirm like rxns with ethanol, and MAO inhibitor type interactions with tyramine containing foods and drinks
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what can be added to the CHOP therapy to make it work better?
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rituximab, anti CD20 monoclonal antibody
FDA approved for indolent follicular lymphomas and large cell lymphoma |
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What treatment regimens are used for nonhodgkins lymphomas?
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CHOP, DHAP, ESHAP, ICE
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CHOP?
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cyclophosphamide, doxorubicin, vincristine, prednisone
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DHAP?
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dexamethasone, highdose cytarabine, cisplatin
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ESHAP
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etopside, methylprednisolone, highdose cytarabine, cisplatin
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ICE
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ifosfamide, carboplatin, etopside
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What to do in indolent limited stage of nodular/follicular nHL?
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wait and watch; cyclophosphamide or fludarabine; RT for local mass
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treatment indolent limited stage disseminated nHL?
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like CLL, chlorambucil or fludarabine
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treatment indolent stage extranodular nHL?
what is H. pylori treatment? |
RT
or for Gastric Malt, H. pylori treatment omeprazole, clarithromycin, bimuth subsalicylate, amox or tetracycline |
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treatment indolent advanced stage nHL?
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conservative vs. R-CVP
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treatment of indolent relapsed nHL?
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Nodular: ritxan or R-CVP
Zevalin or Bexxar bendamustine (+/-R) |
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Treatment for aggressive limited stage nHL?
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CHOP x 3 + RT
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treatment for aggressive advanced stage nHL?
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R-CHOP x 6-8
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Relapsed aggressive nHL?
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if DHAP or ESHAP sensitive do autologous HSCT
not sensitive do DHAP, ESHAP, ICE, (+/-) rituximab |
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How do treat highly aggressive nHL?
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ALL treatments
auto HSCT |
