Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
what is the treatment for low risk - stage 0 CLL?
|
lymphosytosis
no treatment, watch and wait |
|
|
treatment of intermediate risk - stage I/II CLL?
|
lymphadenopathy (+/-) splenomegaly
treat only if progresses chlorambucil or cyclophosphamide |
|
|
treatment of high risk - stage III/IV cll?
|
chlorambucil or cyclophosphamide
younger/healthier use fludarabine or combination chemo fludarabine with rituximab or cyclophosphamide riuximab and cyclophosphamide or chlorambucil sometimes nonhodgkins lymphoma regimins are used: CVP anemia or thrombocytopenia with oranomegaly cyclophosphamide vincristine, prednisone or CHOP which is CVP with doxorubicin |
|
|
Why is prednisone used in CLL?
|
used for autoimmune anemia or thrombocytopenia; can add inraveneous IgG
prednisone adds to immunosuppession of fludarabine |
|
|
What is intraveneous IgG used for?
|
sometimes used for pts with lots of infections, may help reduce number of infections
|
|
|
What is used for relapse in CLL?
|
fludarabine if not already used
combo chemo (CHOP-R) fludarabine-R R = rituximab HSCT if pt is young or nonmyeloblative transplants |
|
|
What was new in April 2008?
|
bendamustine - alkylator/ purine analog
worked well caused myelosupression, N/V, diarrhea 2009 study to see if good first line therapy |
|
|
What is alemtuzumab used for?
|
fludarabine failures
must take prophylactic bactrim and famiciclovir |
|
|
what do you use if alemtuzumab fails?
|
ofatumumab; no CR
|
