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10 Cards in this Set

  • Front
  • Back
What subunits comprise the bacterial ribosome? Which antibiotics work on which?
50S + 30S = 70S

CLEan (50)--PO OK: Chloramphenicol, Clindamycin, Linezolid, Erythromycin

TAG (30) IV ONLY: Tetracycline, Aminoglycosides
Chloramphenicol:
Uses
Side Effects
THE CHLORINE!
Kills most clin impt bact

Uses:
Gram negs
Gram poz
Anaerobes (B FRAGILIS)
Bact meningitis w/unk org with severe PCN allergy
Rocky Mtn Spotted Fever

AE's SEVERE:
Dose related anemia
APLASTIC ANEMIA
GRAY BABY SYNDROME (babies can't conjugate/clear)
Clindamycin:
Uses
Side Effects
Anaerobes: B FRAGILIS (used when GI tract may be perforated thus spilling anaerobes and gram negs into peritoneum)
Genital tract infections

Often combined with beta-lactam or Vanco for TSS

AE: PSEUDOMEMBRANOUS COLITIS!! (destroy normal flora of GI and C difficile grows like crazy)

NOT GRAM NEGS

Note: not just clinda that causes pseudomembranous colitis, may be all of PCN family
Treatment for pseudomembranous colitis.
A VAN and METRO in the GI run over ulcers with c. difficile

Vancomycin
Metronizadole
Linelozid:
Uses
GODZILLA LIZARD stamps out gram poz

Inhibits 50S

Active against MRSA, Vanco Res Enterococcus

$$$$$$
Macrolides:
Examples (3)
Uses
Side Effects
Macrolides:
A wreath!
Erythromycin
Telithromycin
Azithromyzin

(Telithromycin = Ketolide)

Inhibits 50S, braod spec including ATYPICALS

Uses:
Legionella (wreath around Legionnaire's grave)
Chlamydia pneumoniae
Mycoplasma
Tetracycline/Doxycycline
Uses
Side Effects
Soldier in TET offensive: jungles, prostitutes, acne!

(Chelates with cations in milk and passes GI sans absorptn)

Chlamydia tracho...
Mycoplasma pneumoniae
Brucells, Rickettsia (Animal/Tickborne)

AE's:
Phototoxic Dermatitis
Renal/Hepatic Toxicity
DISCOLORED TEETH
Depressed Bone Growth
Aminoglycosides:
Uses
Examples
Side Effects
Aminoglycosides:
A MEAN GUY!

Kills aerobig gram negs enterics (E Coli)
Kills pseudomona
Ends with mycin (gen)

Streptomycin (old; resistance)
Gentamycin (common; resistance)
Tobramycin
Amikacin (Broad)
Neomycin (broad; TOXIC; TOPICAL ONLY)
Netilmicin

AE's:
In 8th round, A MEAN GUY punches opponent in ear-->CN VIII toxicity (vertigo, hearing loss irreversible)

RIGHT hook to KIDNEY-->Renal Toxicity

Opponent drops to floor->NM BLOCKADE
Quinupristin/Dalfopristin:
Uses
Side Effects
NASTY NASTY MEDS

Use only if life-threatening VRE infection:
Enterococcus facium ONLY
UM, YES

ENterococcus faecalis
IS, NO
Spectinomycin:
Uses
NOT AN AMINIOGLYCOSIDE

SPECTACULAR spectinomycin

Use: gonorrhea when resist to pcn AND tetra/doxy or with PCN allergy

AE's: minor