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10 Cards in this Set
- Front
- Back
What subunits comprise the bacterial ribosome? Which antibiotics work on which?
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50S + 30S = 70S
CLEan (50)--PO OK: Chloramphenicol, Clindamycin, Linezolid, Erythromycin TAG (30) IV ONLY: Tetracycline, Aminoglycosides |
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Chloramphenicol:
Uses Side Effects |
THE CHLORINE!
Kills most clin impt bact Uses: Gram negs Gram poz Anaerobes (B FRAGILIS) Bact meningitis w/unk org with severe PCN allergy Rocky Mtn Spotted Fever AE's SEVERE: Dose related anemia APLASTIC ANEMIA GRAY BABY SYNDROME (babies can't conjugate/clear) |
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Clindamycin:
Uses Side Effects |
Anaerobes: B FRAGILIS (used when GI tract may be perforated thus spilling anaerobes and gram negs into peritoneum)
Genital tract infections Often combined with beta-lactam or Vanco for TSS AE: PSEUDOMEMBRANOUS COLITIS!! (destroy normal flora of GI and C difficile grows like crazy) NOT GRAM NEGS Note: not just clinda that causes pseudomembranous colitis, may be all of PCN family |
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Treatment for pseudomembranous colitis.
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A VAN and METRO in the GI run over ulcers with c. difficile
Vancomycin Metronizadole |
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Linelozid:
Uses |
GODZILLA LIZARD stamps out gram poz
Inhibits 50S Active against MRSA, Vanco Res Enterococcus $$$$$$ |
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Macrolides:
Examples (3) Uses Side Effects |
Macrolides:
A wreath! Erythromycin Telithromycin Azithromyzin (Telithromycin = Ketolide) Inhibits 50S, braod spec including ATYPICALS Uses: Legionella (wreath around Legionnaire's grave) Chlamydia pneumoniae Mycoplasma |
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Tetracycline/Doxycycline
Uses Side Effects |
Soldier in TET offensive: jungles, prostitutes, acne!
(Chelates with cations in milk and passes GI sans absorptn) Chlamydia tracho... Mycoplasma pneumoniae Brucells, Rickettsia (Animal/Tickborne) AE's: Phototoxic Dermatitis Renal/Hepatic Toxicity DISCOLORED TEETH Depressed Bone Growth |
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Aminoglycosides:
Uses Examples Side Effects |
Aminoglycosides:
A MEAN GUY! Kills aerobig gram negs enterics (E Coli) Kills pseudomona Ends with mycin (gen) Streptomycin (old; resistance) Gentamycin (common; resistance) Tobramycin Amikacin (Broad) Neomycin (broad; TOXIC; TOPICAL ONLY) Netilmicin AE's: In 8th round, A MEAN GUY punches opponent in ear-->CN VIII toxicity (vertigo, hearing loss irreversible) RIGHT hook to KIDNEY-->Renal Toxicity Opponent drops to floor->NM BLOCKADE |
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Quinupristin/Dalfopristin:
Uses Side Effects |
NASTY NASTY MEDS
Use only if life-threatening VRE infection: Enterococcus facium ONLY UM, YES ENterococcus faecalis IS, NO |
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Spectinomycin:
Uses |
NOT AN AMINIOGLYCOSIDE
SPECTACULAR spectinomycin Use: gonorrhea when resist to pcn AND tetra/doxy or with PCN allergy AE's: minor |