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182 Cards in this Set
- Front
- Back
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increased vascular smooth muscle contraction
receptor type? |
alpha1
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alpha 1 receptor
G protein class? |
Gq
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increased vascular smooth muscle contraction
G-protein class? |
Gq
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decreased sympathetic outflow
decreased insulin release receptor type? |
alpha2
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decreased sympathetic outflow
decreased insulin release G-protein class? |
Gi
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alpha 2 receptor
G-protein class? |
Gi
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increased heart rate
increased contractility increased renin increased lipolysis increased aqueous humor receptor type? |
beta 1
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increased heart rate
increased contractility increased renin increased lipolysis increased aqueous humor G-protein type? |
Gs
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Beta1 receptor
G-protein type? |
Gs
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Vasodilation
bronchodilation increased glucagon release receptor type? |
beta 2
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Vasodilation
bronchodilation increased glucagon release G protein type? |
Gs
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beta 2 receptor
G protein type? |
Gs
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where in the nervous system do you find M1 receptors?
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CNS
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M1 receptor
G protein type? |
Gq
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decrease heart rate
receptor type |
M2
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Decrease heart rate
G protein type? |
Gi
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M2 receptor
G-protein type? |
Gi
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Increase exocrine gland secretions
receptor type? |
M3
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Increase exocrine gland secretions
G protein type? |
Gq
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Relaxes renal vascular smooth muscle
Receptor type? |
D1
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Relaxes renal vascular smooth muscle
G protein type? |
Gs
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Modulates transmitter release especially in brain
Receptor type? |
D2
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Modulates transmitter release especially in brain
G protein type |
Gi
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increased nasal and bronchial mucus production, contraction of bronchioles, pruritus, and pain
Receptor type? |
H1
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increased nasal and bronchial mucus production, contraction of bronchioles, pruritus, and pain
G protein type? |
Gq
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Increse gastric acid secretion
Receptor type |
H2
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Increase gastric acid secretion
G protein type? |
Gs
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Increase H20 permeability in the collecting tubules of the kidney
receptor type? |
V2
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Increase H20 permeability in the collecting tubules of the kidney
G protein class |
Gs
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M2 receptor
G protein class |
Gi
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M3 receptor
G protein class? |
q
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D1 receptor
G protein class? |
Gs
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D2 receptor
G protein class? |
Gi
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H1 receptor
G protein class? |
Gq
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H2 receptor
G protein class? |
Gs
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V1 receptor
G protein class? |
Gq
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V2 receptor
G protein class? |
Gs
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Phospholipase C stimulation
G protein class? |
Gq
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Adenylcyclase stimulation
G protein class? |
Gs
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Adenylcyclase inhibition
G protein class? |
Gi
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IP3 & DAG
G protein class? |
Gq
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inc cAMP
G protein class? |
Gs
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stim Protein Kinase A
G protein class? |
Gs
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inhib protein kinase A
G protein class? |
Gi
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inc Ca++ and Protein kinase C
G protein class? |
Gq
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Inhibit Choline transporter into presynapticnerve neuron
Drug? |
Hemicholinium
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Inhibit ACh storage
drug? |
Vesamicol
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Inhibit ACh release
Drug? |
Botulinum
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blocks accumulation of noradrenaline and dopamine into synaptic vesicles
drug? |
reserpine
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Blocks NE release
Drug? |
Guanethidine
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stimulates NE release
drug? |
amphetamine
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inhibits NE reuptake
drug? |
cocaine
TCA |
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effect of M1 release modulating receptor on NE release?
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decrease
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effect of AII release modulating receptor on NE release?
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increase
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effect of alpha2 release modulating receptor on NE release?
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decrease
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treatment of postoprative and neurogenic ileus and urinary retention
drug? |
bethanecol
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Activates bowel and bladder smooth muscle; resistant to AChE
drug? |
bethanechol
*B*ethanacol=Bowel and Bladder |
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Bethanechol type of agonist
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direct cholinergic agonist
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Activates ciliary muscle of eye
& pupillary sphincter resists AchE treats glaucoma drug? |
Carbachol, pilocarpine
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Treats postoperative and neurogenic ileus and urinary retention
myasthenia gravis reversal of neuromuscular blockade increases endogenous ACh drug? |
Neostigmine
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treatment of myasthenia gravis
increase endogenous ACh drug? |
pyridostigmine
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Diagnosis of myasthenia gravis
increase endogenous ACh |
Edrophonium
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Treats glaucoma (crosses blood brain barrier into CNS
atropine overdose increase endogenous ACh |
Physostigmine
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Echothiophate
treatment for? |
glaucoma
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Pyridostigmine treatment for?
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Myasthenia gravis
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Edrophonium use?
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diagnosis of myasthenia gravis
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phyiostigmine use?
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tx glaucoma
tx atropine overdose |
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Bethanechol mechanism
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cholinergic direct agonist
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carbachol mechanism
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cholinergic direct agonist
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pilocarpine mechanism
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cholinergic direct agonist
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neostgmine mechanism
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anticholinesterase
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pyridostigmine mechanism
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anticholinesterase
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edrophonium mechanism
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anticholinesterase
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physostigmine mechanism
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anticholinesterase
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mechanism of echothiophate
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anticholinesterase
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antidote to cholinesterase inhibitor poisoning
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atropine and pralidoxime
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atropine use in Eye
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poruduce mydriasis and cyclopplegia
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homatropine use in eye
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produce mydriasis and cycloplegia
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tropicamide use in eye?
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Produce mydreiasis and cyloplegia
(cholinoreceptor blocker) |
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benzotropine use in CNS
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tx of parkinson's
(cholinoreceptor blocker) |
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scopolamine use in CNS?
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tx of motion sickness
(cholinoreceptor blocker) |
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Ipratropium use in respiratory system
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Asthma, COPD
(cholinoreceptor blocker) |
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Methscopolamine use in genitourinary system
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reduce urgency in mild cystiti and reduce bladder spasms
(cholinoreceptor blocker) |
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oxybutin use in genitourinary system
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reduce urgency in mild cystiti and reduce bladder spasms
(cholinoreceptor blocker) |
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glycopyrrolate use in genitourinary system
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reduce urgency in mild cystiti and reduce bladder spasms
(cholinoreceptor blocker) |
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effect of atropine on eye
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increased pupil dilation, cycloplegia
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effect of atropine on airway
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decreased secretion
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effect of atropine on stomach
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decreeased acid
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effect of atropine on gut
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decreased motility
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effect of atroine on bladder
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decreased urgency in cystitis
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hechanism of mexamethonium
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nicotinic ACh receptor Antagonist
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drug which prevents vagal reflex response to changes in blood pressure
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hexamethonium
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direct general agonist
alpha1 alpha2 beta1 beta2 Drug? |
Epinephrine
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Tx of anaphylaxis, glaucoma (open angle), asthma, hypotension
Drug? |
Epinephrine
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selective for alpha1, alpha2, beta1
drug? |
Norepinephrine
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Tx of hypotension (but decreases renal perfusion)
Drug? |
Norepinephrine
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Selectivity: beta1 = beta2 sympathomimetic
Drug? |
Isoproterenol
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Tx of AV block
Drug? |
Isoproterenol
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Selectivity:
D1 = D2 > beta > alpha Drug? |
Dopamine
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Tx of shock (increases renal perfusion) and of herat failure
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Dopamine
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Sympathomimetic:
Beta1> Beta2 Drug? |
Dobutamine
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Tx of shock, heart failure (w/out inc renal perfusion)
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Dobutamine
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Epinephrine
selectivity? |
general agonist
alhpa 1&2, beta 1&2 |
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NE
selectivity? |
alpha1, alpha2, beta1
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Isoproterenol
mechanism? |
beta1 = beta2 sympathomimetic
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dobutamine
selectivity? |
beta1 > beta2
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indirect general agonist, releases stored catecholamines
drug? |
amphetamine, ephedrine
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tx of narcolepsy, obesity, ADD
drug? |
amphetamine
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amphetamine mechanism
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releases stored catecholamines
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tx of nasal congestion, urinary incontinence, hypotension
drug? |
ephedrine
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ephedrine mechanism
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releases stored catecholamines
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selectivity:
alpha1>alpha2 drug? |
phenylephrine
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pupil dilator, vasoconstrictor, nasal decongestant
drug? |
phenylephrine
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phenylephrine selectivity
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alpha1 > alpha2
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Beta2 > Beta1
drug? |
Albuterol
terbutaline |
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Tx of asthma
drug? |
Albuterol
terbutaline |
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Albuterol selectivity
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Beta2 > Beta1
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terbutaline selectivity
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Beta2 > Beta1
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Albuterol clinical use
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tx of asthma
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terbutaline clinical use
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tx of asthma
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catecholamine uptake inhibitor
indirect general agonist drug? |
cocaine
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causes vasoconstriction and local anesthesia
drug? |
cocaine
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cocaine mechanism
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uptake inhibitor
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cocaine clinical use
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local vasoconstriction and anesthesia
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centrally acting alpha agonist, decreased adrenergic outflow
drug? |
clonidine
alpha-methyldopa |
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tx of hypertension, especially with renal disease (no decreased renal blood flow)
drug? |
clonidine
alpha-methyldopa |
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clonidine mechanism
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decreased central adrenergic outflow
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alpha-methyldopa mechanism
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decreased central adrenergic outflow
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clinical use of clonidine
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tx of hypertension w/ renal disease
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clinical use of alpha methyldopa
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tx of hypertensino w/ renal disease
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increased systolic and diastolic blood pressure
drug? |
norepinephrine
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increased systolic pressure
decreased diastolic pressure drug? |
epinephrine
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epinephrine effect on Heart Rate
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increased
(nonselective) |
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norepinephrine effect on Heart Rate
|
decreaseed
(reflexive) (alpha > beta) |
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decreased systolic and diastolic
increased heart rate drug? |
isoproterenol
(beta > alpha) |
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phenoxybenzamine mechanism
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irreversible nonselective alpha blocker
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phenoxybenzamine clinical use
|
pheochromocytoma
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phenoxybenzamine toxicity
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orthostatic hypotension
reflex tachycardia |
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irreversible nonselective alpha blocker
|
phenoxybenzamine
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phentolamine mechanism
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reversible nonselective alpha blocker
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reversible nonselective alpha blocker
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phentolamine
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alpha 1 selective alpha blocker
drug? |
prazosin
terazosin doxazosin |
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mechanism of prazosin
|
alpha 1 blocker
|
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mechanism of terazosin
|
alpha 1 blocker
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mechanism of doxazosin
|
alpha 1 blocker
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tx of urinary retention in BPH
type receptor blocker? |
alpha 1 blocker
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mirtazapine mechanism
|
alpha 2 blocker
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clinical application of mirtazapine
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depression
|
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mirtazapine side effects
|
sedation
increased cholesterol increased appetite |
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effect of alpha blocker on epinephrine respnse
|
paradoxical BP drop
(beta2 response) |
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effect of alpha blocker on blood pressure response to phenylephrine
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suppression of pressor effect
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Beta blocker effect in tx of hypertension
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decreased cardiac output
decreased renin secretion |
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beta blocker effect in tx of angina pectoris
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decreased O2 consumption
(decreased heart rate and contractility) |
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beta blocker effect in tx of Supra Ventricular Tachycardia
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decreased AV conduction velocity
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beta blocker effect in tx of glaucoma
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decreased secretion of aqueous humor
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beta blocker used to tx glaucoma
|
Timolol
betaxolol carteolol |
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neta blocker used to tx Supra Ventricular Tachycardia
|
propanolol
esmolol |
|
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selectivity of propranolol
|
beta 1 = beta 2
(nonselective beta blocker) |
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selectivity of timolol
|
beta 1 = beta 2
(nonselective beta blocker) |
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selectivity of nadolol
|
beta 1 = beta 2
(nonselective beta blocker) |
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selectivity of pindolol
|
beta 1 = beta 2; partial agonist
|
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mechanism of labetalol
|
beta 1 = beta 2; partial agonist
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partial agonist beta blockers
|
pindolol & labetalol
|
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Acebutolol mechanism
|
beta1 selective partial agonist
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Betaxolol selectivity
|
beta1 blocker
|
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esmolol selectivity
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beta 1 selective blocker (short acting)
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atenolol selectivity
|
beta 1 selective blocker
|
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metoprolol selectivity
|
beta 1 selective blocker
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epinephrine mechanism in tx of glaucoma
|
increased outflow of aqueous humor
(not for closed angle glaucoma) (mydriasis) |
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brimonidine mechanism in tx of glaucoma
|
decreased humor synthesis
|
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alpha agonists used in glaucoma tx
|
epinephrine
brimonidine |
|
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timolol mechanism in glaucoma tx
|
decreased aqueous humor secretion
|
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betaxolol mechanism in glaucoma tx
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decreased aqueous humor secretion
|
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carteolol mechanism in glaucoma tx
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decreased aqueous humor secretion
|
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beta blockers used to tx glaucoma
|
Timolol
betaxolol carteolol |
|
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acetazolamide mechanism in tx of glaucoma
|
decreased HCO3- -> decreased aqueous humor secretion
(via inhibition of carbonic anhyrase) |
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diuretics used to tx glaucoma
|
acetazolamide
|
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pilocarpine mechanism in tx of glaucoma
|
increased outflow of aqueous humor
(from contraction of ciliary muscle) (causes miosis) |
|
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carbachol mechanism in tx of glaucoma
|
increased outflow of aqueous humor
(from contraction of ciliary muscle) (causes miosis) |
|
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physostigmine in tx of glaucoma
|
increased outflow of aqueous humor
(from contraction of ciliary muscle) (causes miosis) |
|
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echothiophate mechanism in tx of glaucoma
|
increased outflow of aqueous humor
(from contraction of ciliary muscle) (causes miosis) |
|
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latanoprost (PGF2a) mechanism in tx of glaucoma
|
increased outflow of aqueous humor
|
