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182 Cards in this Set

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increased vascular smooth muscle contraction

receptor type?
alpha1
alpha 1 receptor

G protein class?
Gq
increased vascular smooth muscle contraction

G-protein class?
Gq
decreased sympathetic outflow
decreased insulin release

receptor type?
alpha2
decreased sympathetic outflow
decreased insulin release

G-protein class?
Gi
alpha 2 receptor

G-protein class?
Gi
increased heart rate
increased contractility
increased renin
increased lipolysis
increased aqueous humor

receptor type?
beta 1
increased heart rate
increased contractility
increased renin
increased lipolysis
increased aqueous humor

G-protein type?
Gs
Beta1 receptor

G-protein type?
Gs
Vasodilation
bronchodilation
increased glucagon release

receptor type?
beta 2
Vasodilation
bronchodilation
increased glucagon release

G protein type?
Gs
beta 2 receptor

G protein type?
Gs
where in the nervous system do you find M1 receptors?
CNS
M1 receptor

G protein type?
Gq
decrease heart rate

receptor type
M2
Decrease heart rate

G protein type?
Gi
M2 receptor

G-protein type?
Gi
Increase exocrine gland secretions

receptor type?
M3
Increase exocrine gland secretions

G protein type?
Gq
Relaxes renal vascular smooth muscle

Receptor type?
D1
Relaxes renal vascular smooth muscle

G protein type?
Gs
Modulates transmitter release especially in brain

Receptor type?
D2
Modulates transmitter release especially in brain

G protein type
Gi
increased nasal and bronchial mucus production, contraction of bronchioles, pruritus, and pain

Receptor type?
H1
increased nasal and bronchial mucus production, contraction of bronchioles, pruritus, and pain

G protein type?
Gq
Increse gastric acid secretion

Receptor type
H2
Increase gastric acid secretion

G protein type?
Gs
Increase H20 permeability in the collecting tubules of the kidney

receptor type?
V2
Increase H20 permeability in the collecting tubules of the kidney

G protein class
Gs
M2 receptor

G protein class
Gi
M3 receptor

G protein class?
q
D1 receptor

G protein class?
Gs
D2 receptor

G protein class?
Gi
H1 receptor

G protein class?
Gq
H2 receptor

G protein class?
Gs
V1 receptor

G protein class?
Gq
V2 receptor

G protein class?
Gs
Phospholipase C stimulation

G protein class?
Gq
Adenylcyclase stimulation

G protein class?
Gs
Adenylcyclase inhibition

G protein class?
Gi
IP3 & DAG

G protein class?
Gq
inc cAMP

G protein class?
Gs
stim Protein Kinase A

G protein class?
Gs
inhib protein kinase A

G protein class?
Gi
inc Ca++ and Protein kinase C

G protein class?
Gq
Inhibit Choline transporter into presynapticnerve neuron

Drug?
Hemicholinium
Inhibit ACh storage

drug?
Vesamicol
Inhibit ACh release

Drug?
Botulinum
blocks accumulation of noradrenaline and dopamine into synaptic vesicles

drug?
reserpine
Blocks NE release

Drug?
Guanethidine
stimulates NE release

drug?
amphetamine
inhibits NE reuptake

drug?
cocaine
TCA
effect of M1 release modulating receptor on NE release?
decrease
effect of AII release modulating receptor on NE release?
increase
effect of alpha2 release modulating receptor on NE release?
decrease
treatment of postoprative and neurogenic ileus and urinary retention

drug?
bethanecol
Activates bowel and bladder smooth muscle; resistant to AChE

drug?
bethanechol

*B*ethanacol=Bowel and Bladder
Bethanechol type of agonist
direct cholinergic agonist
Activates ciliary muscle of eye
& pupillary sphincter
resists AchE

treats glaucoma

drug?
Carbachol, pilocarpine
Treats postoperative and neurogenic ileus and urinary retention
myasthenia gravis
reversal of neuromuscular blockade

increases endogenous ACh

drug?
Neostigmine
treatment of myasthenia gravis
increase endogenous ACh

drug?
pyridostigmine
Diagnosis of myasthenia gravis

increase endogenous ACh
Edrophonium
Treats glaucoma (crosses blood brain barrier into CNS
atropine overdose

increase endogenous ACh
Physostigmine
Echothiophate

treatment for?
glaucoma
Pyridostigmine treatment for?
Myasthenia gravis
Edrophonium use?
diagnosis of myasthenia gravis
phyiostigmine use?
tx glaucoma
tx atropine overdose
Bethanechol mechanism
cholinergic direct agonist
carbachol mechanism
cholinergic direct agonist
pilocarpine mechanism
cholinergic direct agonist
neostgmine mechanism
anticholinesterase
pyridostigmine mechanism
anticholinesterase
edrophonium mechanism
anticholinesterase
physostigmine mechanism
anticholinesterase
mechanism of echothiophate
anticholinesterase
antidote to cholinesterase inhibitor poisoning
atropine and pralidoxime
atropine use in Eye
poruduce mydriasis and cyclopplegia
homatropine use in eye
produce mydriasis and cycloplegia
tropicamide use in eye?
Produce mydreiasis and cyloplegia
(cholinoreceptor blocker)
benzotropine use in CNS
tx of parkinson's
(cholinoreceptor blocker)
scopolamine use in CNS?
tx of motion sickness
(cholinoreceptor blocker)
Ipratropium use in respiratory system
Asthma, COPD
(cholinoreceptor blocker)
Methscopolamine use in genitourinary system
reduce urgency in mild cystiti and reduce bladder spasms
(cholinoreceptor blocker)
oxybutin use in genitourinary system
reduce urgency in mild cystiti and reduce bladder spasms

(cholinoreceptor blocker)
glycopyrrolate use in genitourinary system
reduce urgency in mild cystiti and reduce bladder spasms

(cholinoreceptor blocker)
effect of atropine on eye
increased pupil dilation, cycloplegia
effect of atropine on airway
decreased secretion
effect of atropine on stomach
decreeased acid
effect of atropine on gut
decreased motility
effect of atroine on bladder
decreased urgency in cystitis
hechanism of mexamethonium
nicotinic ACh receptor Antagonist
drug which prevents vagal reflex response to changes in blood pressure
hexamethonium
direct general agonist
alpha1
alpha2
beta1
beta2

Drug?
Epinephrine
Tx of anaphylaxis, glaucoma (open angle), asthma, hypotension

Drug?
Epinephrine
selective for alpha1, alpha2, beta1

drug?
Norepinephrine
Tx of hypotension (but decreases renal perfusion)

Drug?
Norepinephrine
Selectivity: beta1 = beta2 sympathomimetic

Drug?
Isoproterenol
Tx of AV block

Drug?
Isoproterenol
Selectivity:
D1 = D2 > beta > alpha

Drug?
Dopamine
Tx of shock (increases renal perfusion) and of herat failure
Dopamine
Sympathomimetic:
Beta1> Beta2
Drug?
Dobutamine
Tx of shock, heart failure (w/out inc renal perfusion)
Dobutamine
Epinephrine

selectivity?
general agonist

alhpa 1&2, beta 1&2
NE

selectivity?
alpha1, alpha2, beta1
Isoproterenol

mechanism?
beta1 = beta2 sympathomimetic
dobutamine

selectivity?
beta1 > beta2
indirect general agonist, releases stored catecholamines

drug?
amphetamine, ephedrine
tx of narcolepsy, obesity, ADD

drug?
amphetamine
amphetamine mechanism
releases stored catecholamines
tx of nasal congestion, urinary incontinence, hypotension

drug?
ephedrine
ephedrine mechanism
releases stored catecholamines
selectivity:
alpha1>alpha2

drug?
phenylephrine
pupil dilator, vasoconstrictor, nasal decongestant

drug?
phenylephrine
phenylephrine selectivity
alpha1 > alpha2
Beta2 > Beta1

drug?
Albuterol
terbutaline
Tx of asthma

drug?
Albuterol
terbutaline
Albuterol selectivity
Beta2 > Beta1
terbutaline selectivity
Beta2 > Beta1
Albuterol clinical use
tx of asthma
terbutaline clinical use
tx of asthma
catecholamine uptake inhibitor
indirect general agonist

drug?
cocaine
causes vasoconstriction and local anesthesia

drug?
cocaine
cocaine mechanism
uptake inhibitor
cocaine clinical use
local vasoconstriction and anesthesia
centrally acting alpha agonist, decreased adrenergic outflow

drug?
clonidine
alpha-methyldopa
tx of hypertension, especially with renal disease (no decreased renal blood flow)

drug?
clonidine
alpha-methyldopa
clonidine mechanism
decreased central adrenergic outflow
alpha-methyldopa mechanism
decreased central adrenergic outflow
clinical use of clonidine
tx of hypertension w/ renal disease
clinical use of alpha methyldopa
tx of hypertensino w/ renal disease
increased systolic and diastolic blood pressure

drug?
norepinephrine
increased systolic pressure
decreased diastolic pressure

drug?
epinephrine
epinephrine effect on Heart Rate
increased
(nonselective)
norepinephrine effect on Heart Rate
decreaseed
(reflexive)
(alpha > beta)
decreased systolic and diastolic
increased heart rate

drug?
isoproterenol
(beta > alpha)
phenoxybenzamine mechanism
irreversible nonselective alpha blocker
phenoxybenzamine clinical use
pheochromocytoma
phenoxybenzamine toxicity
orthostatic hypotension
reflex tachycardia
irreversible nonselective alpha blocker
phenoxybenzamine
phentolamine mechanism
reversible nonselective alpha blocker
reversible nonselective alpha blocker
phentolamine
alpha 1 selective alpha blocker

drug?
prazosin
terazosin
doxazosin
mechanism of prazosin
alpha 1 blocker
mechanism of terazosin
alpha 1 blocker
mechanism of doxazosin
alpha 1 blocker
tx of urinary retention in BPH

type receptor blocker?
alpha 1 blocker
mirtazapine mechanism
alpha 2 blocker
clinical application of mirtazapine
depression
mirtazapine side effects
sedation
increased cholesterol
increased appetite
effect of alpha blocker on epinephrine respnse
paradoxical BP drop
(beta2 response)
effect of alpha blocker on blood pressure response to phenylephrine
suppression of pressor effect
Beta blocker effect in tx of hypertension
decreased cardiac output
decreased renin secretion
beta blocker effect in tx of angina pectoris
decreased O2 consumption
(decreased heart rate and contractility)
beta blocker effect in tx of Supra Ventricular Tachycardia
decreased AV conduction velocity
beta blocker effect in tx of glaucoma
decreased secretion of aqueous humor
beta blocker used to tx glaucoma
Timolol
betaxolol
carteolol
neta blocker used to tx Supra Ventricular Tachycardia
propanolol
esmolol
selectivity of propranolol
beta 1 = beta 2
(nonselective beta blocker)
selectivity of timolol
beta 1 = beta 2
(nonselective beta blocker)
selectivity of nadolol
beta 1 = beta 2
(nonselective beta blocker)
selectivity of pindolol
beta 1 = beta 2; partial agonist
mechanism of labetalol
beta 1 = beta 2; partial agonist
partial agonist beta blockers
pindolol & labetalol
Acebutolol mechanism
beta1 selective partial agonist
Betaxolol selectivity
beta1 blocker
esmolol selectivity
beta 1 selective blocker (short acting)
atenolol selectivity
beta 1 selective blocker
metoprolol selectivity
beta 1 selective blocker
epinephrine mechanism in tx of glaucoma
increased outflow of aqueous humor
(not for closed angle glaucoma)
(mydriasis)
brimonidine mechanism in tx of glaucoma
decreased humor synthesis
alpha agonists used in glaucoma tx
epinephrine
brimonidine
timolol mechanism in glaucoma tx
decreased aqueous humor secretion
betaxolol mechanism in glaucoma tx
decreased aqueous humor secretion
carteolol mechanism in glaucoma tx
decreased aqueous humor secretion
beta blockers used to tx glaucoma
Timolol
betaxolol
carteolol
acetazolamide mechanism in tx of glaucoma
decreased HCO3- -> decreased aqueous humor secretion

(via inhibition of carbonic anhyrase)
diuretics used to tx glaucoma
acetazolamide
pilocarpine mechanism in tx of glaucoma
increased outflow of aqueous humor
(from contraction of ciliary muscle)
(causes miosis)
carbachol mechanism in tx of glaucoma
increased outflow of aqueous humor
(from contraction of ciliary muscle)
(causes miosis)
physostigmine in tx of glaucoma
increased outflow of aqueous humor
(from contraction of ciliary muscle)
(causes miosis)
echothiophate mechanism in tx of glaucoma
increased outflow of aqueous humor
(from contraction of ciliary muscle)
(causes miosis)
latanoprost (PGF2a) mechanism in tx of glaucoma
increased outflow of aqueous humor