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29 Cards in this Set
- Front
- Back
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TYPE I hypersensitivity is ______ mediated
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IgE, this is a "histamine" hyper sens. associated with allergic rhinitis, eczema, hives, asthma, and anaphylaxis
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Type I hypersensivity's response is unique in that
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the first dose is okay, then the 2nd dose has a histamine response
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When thinking of Type I hypersensitivity, how is the body protecting itself?
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"flusing out" the antigen by the exudation response of histamine
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what type of hypersensitivity is Type II?
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antibody- mediated
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what is the mechanism of type II hypersensitivity?
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antibody-antigen->complement-> membrane attack complex
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what occurs during pregnancy when the momma is RH-?
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rh- is okay as along as baby is rh-. if the first baby is rh+ then the subsequent pregnancies can result in hydrops fetalis.
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what is the type of hypersensitivity in type III?
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immune complex deposition
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what is main "protective" reason of type II hypersensitivity?
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Kill off the antigen that the body sees as foreign
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what is the hypersensitivity type in type IV hypersensitivity?
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cell-mediated
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what type of hypersen. is in hyper acute rejection?
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type II
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what is the body reacting to in Hyper acute rejection?
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Hyper Acute= Hla Antribodies
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what type of hypersensitivity is active in Acute rejection?
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Type IV
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what type of hypersensitivity is in chronic rejection?
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Type II, III
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In graft versus host disease the _____ is acting against _____ with type _____ hypersensitivtity?
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Graft, host, IV
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what is the oncogene in burkitt lymphoma?
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C-myc
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what is the oncogene in Chronic Myleogenous leukemia?
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c-abl
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what is the oncogene in colon carcinoma?
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Ras
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what is the suppressor gene that is mutated in breast/ovarian cancer?
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BRCA-1
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what is the suppressor gene in breast, colon, lung carcinoma?
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p53
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what is the tumor marker for adenocarcinoma?
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CEA
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what is the tumor marker in downs?
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low AFP
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what is the tumor marker in neural tube defects?
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HiGH AFP
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what is the tumor marker in prostate cancer?
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PSA, acid phosphatase
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what is the tumor marker in bone cancer?
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alk. phos.
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what is the tumor marker in renal cell carcinoma?
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alk. phos
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what is the tumor marker used for non-neoplastic biliary disease?
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alk. phos.
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what will be elevated in pregnancy? why?
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alk. phos.
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what is MOST likely metastasis in breast cancer? second most?
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Bone, brain
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what is the most likely metastasis in lung cancer? second most?
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brain, bone
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