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29 Cards in this Set
- Front
- Back
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Physostigmine and neostigmine - what is their MOA and what do they treat?
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cholinesterase (-)'s
treatment of myasthenia gravis |
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physostigmine is used to treat overdose with what?
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anticholinergics
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What drug is used to diagnose myasthenia gravis? what is its MOA?
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Edrophonium
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What are organophosphates used to treat?
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closed angle glaucoma
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What is the antidote for overdose with organophosphates?
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atropine and pralidoxime (2-PAM)
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diaphoresis, flushing, increased urinary urgency, nausea and diarrhea are the major ADRs or what kind of drugs?
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direct cholinergic drugs
SLUDGE - salivation, lacrimation, urination, defecation, GI upset, emesis |
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Bethanechol is used for what?
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atonic bladder
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Pilocarpine is used for what?
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acute angle glaucoma
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Carbachol is used or what and how is it administered?
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glaucoma via eyedrops
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Anti-muscarinic or anticholinergic drugs - 2?
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atropine
scopolamine |
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What drug is used for motion sickness?
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scopolamine - anti-muscarinic
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What anti-muscarinic drug is used for reversal of bradycardia and reduction of hyperactive bladder?
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atropine
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What are the major ADRs associated with anti-muscarinic/anticholinergics?
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urinary retention, dry mouth, blurred vision, tachycardia, etc.
dry as a bone mad as a hatter hot as a hare blind as a bat |
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What is the primary use of antinicotinic drugs?
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complete muscle relaxation (paralysis) - surgery
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What are the 3 antinicotinic blockers?
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tubocurarine
pancuronium succinylcholine |
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What 3 drugs must you use caution with when using the antinicotinic drugs?
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halothane
aminoglycosides Calcium channel blockers |
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What antinicotinic drug is used for rapid endotracheal intubation, electroconvulsive shock therapy and surgery?
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Succinylcholine
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what antinicotinic drug has a risk for malignant hyperthermia?
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succinylcholine
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What is the treatment for malignant hyperthermia?
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dantrolene
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What are the 2 types of cholinergic receptors?
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nicotinic and muscarinic
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What muscarinic receptors are found in the CNS?
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M4 and M5
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What muscarinic receptors are found on the heart?
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M2
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what muscarinic receptors STIMULATE PLC which produces IP3 and DAG to increase Cai?
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M1, 3 and 5
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Which muscarinic receptors INHIBIT adenylate cyclase, decreasing cAMP and causing K efflux and Na influx?
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M2 and M4
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what is the result of beta receptors?
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stimulate adenylate cyclase = high cAMP
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what is the result of Alpha 1 receptors?
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stimulate PLC = high calcium
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what is the result of Alpha 2 receptors?
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inhibits adenylate cyclase = low cAMP
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What are the 6 common side effects of estrogen treatment?
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breakthrough bleeding
Nausea/vomitting breast tenderness HTN skin pigmentation |
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What are the 3 major side effects of treatment with progesterones?
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weight gain
depression hirsutism/acne |
