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33 Cards in this Set

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PGI2:
vasodilator, inhibits platelet aggregation
Proteins C and S:
inactivate factors V and VIII, enhance fibrinolysis
vWF:
platelet adhesion; prevents degradation of VIII:C
Tissue thromboplastin:
activates factor VII in extrinsic coagulation system
Platelet receptors:
GpIb (binds to vWF) GpIIb/IIIa (binds to fibrinogen)
Important platelet storage proteins:
vWF, fibrinogen
Final common pathway:
factors X, V, II, I
Factor XIII:
cross-links insoluble fibrin monomers
Calcium:
binds y-carboxylated vitamin K-dependent factors
Warfarin:
inhibits epoxide reductase; vitamin K is nonfunctional
d-Dimers:
cross-linked fibrin monomers
Platelet sequence:
adhesion, release reaction, synthesis TXA2, temporary plug
Aspirin or NSAIDs:
Platelet aggregation defect. Inhibition of platelet COX, which ultimately inhibits synthesis of TXA2
Bernard-Soulier syndrome:
Platelet adhesion defect. Absent GpIb platelet receptors for vWF
Glanzmann's disease:
Platelet aggregation defect. Autosomal recessive disease. Absent GpIIb-IIIa fibrinogen receptors. Absent thrombosthenin.
Von Willebrand disease:
Platelet adhesion defect. Absent or defective vWF. Decreased VIII:C
Ristocetin cofactor assay:
test of vWF function
FDPs:
increased with lysis of fibrinogen or fibrin in fibrin thrombi
d-Dimer assay:
specific for lysis of fibrin thrombi (clots)
Acute idiopathic thrombocytopenic purpura (ITP):
IgG antibodies directed against GpIIb:IIIa receptors (type II hypersensitivity reaction). Macrophages phagocytose platelets.
Chronic Idiopathic thrombocytopenic purpura:
IgG antibodies directed against GpIIb:IIIa receptors (type II hypersensitivity reaction)
Heparin-induced thrombocytopenia:
Type II variant: macrophage removal of platelets surfaced by IgG antibody directed against heparin attached to PF4 (type II sensitivity)
HIV thrombocytopenia:
Similar to ITP
Thrombotic thrombocytopenic purpura (TTP):
Acquired or genetic deficiency in vWF-cleaving metalliprotease in endothelial cells. Excess of vWF increases platelet adhesion to areas of endothelial injury at arteriole-capillary junctions. Platelets consumed in the formation of thrombi causes thrombocytopenia. Enhanced by factors that damage endothelial cells (e.g. ticlopidine, hypertension)
Hemolytic uremic syndrome (HUS):
Edothelial damage at arteriole-capillary junction caused by Shiga-like toxin of 0157:H7 serotype of Escherichia coli. Organisms proliferate in undercooked beef.
Hemophilia A:
decrease VIII:C, VIII:Ag; increase PTT
Primary fibrinolysis:
positive test for FDPs, negative d-dimer assay
Anticardiolipin antibody:
produces a false-positive syphilis serologic test
Hemorrhagic skin necrosis:
associated with warfarin therapy in protein C deficiency
Hemophilia A:
decrease VIII:C, VIII:Ag; increase PTT
Primary fibrinolysis:
positive test for FDPs, negative d-dimer assay
Anticardiolipin antibody:
produces a false-positive syphilis serologic test
Hemorrhagic skin necrosis:
associated with warfarin therapy in protein C deficiency