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66 Cards in this Set
- Front
- Back
Non-Boney Features of Marfan's
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Aortic root dilation
Occular lens dislocation High arched palate Dislocating patellae NO HYDRONEPHROSIS |
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Morquio Syndrome patients must undergo __________.
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C-spine films to r/o instability and spinal cord compression leading to ataxia.
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Features of achondroplasia.
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Bowed, short extremities
Foramen magnum stenosis Lumbar spinal stenosis Thoracolumbar kyphosis NO BLUE SCLERAE/TEETH |
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Primary organic and inorganic component of bone.
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Type I collagen
hydroxyapatite |
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Femoral head with avascular necrosis undergoes subchondral fracture:
How? |
Fatigue failure
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Enzyme used to resorb bone.
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Acid phosphatase
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Wolff's Law
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form follows function
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Right foot slap
Dec'd strength in right great toe Sensation diminished over dorsum Reflexes normal: Cause? Dx? |
Herniation of fifth lumbar nerve root
Needs MRI of lumbosacral spine |
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Polyarticular, symmetric stiffness, pain
PIPs, MCPs, wrists swollen Bumps on elbows Extra-articular findings? T-cell involved? |
RA:
Ocular inflammation ILD Carpal tunnel Npenia, splenomegaly NO GN Th1 involved |
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TNF-alpha, IL-1:
Role |
Stimulate macs
Endothelial cells-->adhesion molecs, VEGF Hepatocytes-->CRP Stimulate B synovial cells-->MMPs |
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Pin in hands, hip, knee
Bumps over DIP: Pathogenesis |
Osteoarthritis--most common form of arthritis, may have been precipitated by prior injury; likely non-inflammatory
Subchondral bone becomes sclerotic, develops cysts Cartilage becomes soft, fibrillated Chondrocytes make more preoteoglycan, collegen Upreg'd MMPs, dec'd TIMPs |
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Positive birefringence:
Screen for? |
Hypothy
Hyperpara Hemochromatosis Hypercal |
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Meniscal cartilage has the potential for healing with ______.
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Peripheral tears
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What increases risk of osteoarthritis?
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Weight gain
Joint malalignment Age Muscle atrophy NOT osteoporosis |
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This is a feature of ligament tissue in the toe region during a stress strain.
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Crimp pattern
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A shoulder dislocation is considered what grade of strain?
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Grade 3
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Role of ACL
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Primary stabilizer of knee joint
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DMARD associated with retinal toxicity
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Hydroxychloroquine
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These drugs prevent TNF-alpha from binding.
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Enteracept
Infliximab |
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Cause of death in infant with OI.
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Lung hypoplasia
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OI involves a defect in collagen type ___.
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Type I
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Osteitis fibrosa cystica (brown tumor of bone).
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Hyperpara
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Osteomalacia:
Pathophys |
Dec'd mineralization of skeleton due to lack of vitamin D (Adult Ricket's!)
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Inactive, postmenopausal women are at risk of ______.
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Spinal compression fracture
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Avascular necrosis:
Cause |
Sickle Cell
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Enlarged costochondral junctions forming rosary.
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Rickets
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Rheumatoid arthritis involves this T cell.
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Th1, CD4
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Risk factors for gout.
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Diuretics, cyclosporine
Renal insufficiency EtOH Genes |
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This arthritis is sytsemic.
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Rheumatoid
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This arthritis is limited to articular structures.
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OA
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RA involves Class ___ MHC antigens.
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Class II MHC
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HLA-DR4
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Inc'd risk of RA in white ppl
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dsDNA is associated with ____.
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Renal disease
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SS-A is associated with ______.
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Subacute cutaneous lupus
Neonatal lupus |
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OA:
Pathophys |
Inc'd MMPs
Dec'd TIMPs |
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9:1 male predominance
Iritis, conjunctivitis Salmonella, chlamydia |
Reactive arthritis
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HGPRT
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If low-->inc'd de novo purine synthesis
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This antibody is associated with SLE, but NOT diagnostic.
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ANA
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This antibody is specific for SLE.
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dsDNA
Anti-Smith |
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Tophi can lead to _____.
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Erosion
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HLA-B27
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**Ankylosing spondylitis**
Psoriatic arthritis |
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How can OA be distinguished from RA?
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Pattern of joint involvement
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Extraarthritic features of SLE
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Photosens skin rash
Pleuritic chest pain Oral ulcers (Arthritis) |
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SLE is not associated with ______ ethnicity.
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Caucasian
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Type II collagen is prevalent in _____.
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Articular cartilage
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What is the smallest bone unit?
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Osteon
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Oxygen tension is greatest in this growin zone of physis ________.
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Proliferative
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What tissue has the lowest percentage of water content?
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Bone
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Women falls and lands on food with knee extended.
What is likely injured? |
Tibial plateau
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This disorder has normal bone mineralization.
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Osteoporosis
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This cell type is abnormal in osteopetrosis.
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Osteoclast
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Most rotator cuff tears are _____.
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Atraumatic
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What percent of hip fracture patients regain their preinjury ambulatory status?
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50%
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Physeal fracture in child likely to develop bony bridge that will alter growth and development.
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Salter Type IV
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Osteoporotic fractures might be best prevented by _____.
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Inc'd Ca2+ intake during adolescence
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Articular cartilage repair resulting in hyaline-cartilage.
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Autologous chondrocyte transplant
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Anti-DNA topoisomerase is associated with _______.
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Diffuse Scleroderma (PSS)
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Anti-histone is associated with ______.
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Drug-induced SLE
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Anti-Sm is associated with _______.
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SLE
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Kidney pathology in PSS is secondary to ______.
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Fibrosis of vessel walls-->ischemia
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How does SLE differ from PSS in dermal deposition?
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SLE: liquefactive degeneration of basal epidermis, edema
PSS: Deposition of collagen in dermis, thinning of epidermis |
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Complement deposition in perimysium.
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Dermatomyositis
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Mediated by direct T-cell attack.
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Polymyositis
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Flexion-contraction without joint involvement
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PSS
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Complement deposition in basement membranes
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SLE
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Cartilage erosion, eburnated articular surface
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OA
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