• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/66

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

66 Cards in this Set

  • Front
  • Back
Non-Boney Features of Marfan's
Aortic root dilation
Occular lens dislocation
High arched palate
Dislocating patellae

NO HYDRONEPHROSIS
Morquio Syndrome patients must undergo __________.
C-spine films to r/o instability and spinal cord compression leading to ataxia.
Features of achondroplasia.
Bowed, short extremities
Foramen magnum stenosis
Lumbar spinal stenosis
Thoracolumbar kyphosis

NO BLUE SCLERAE/TEETH
Primary organic and inorganic component of bone.
Type I collagen
hydroxyapatite
Femoral head with avascular necrosis undergoes subchondral fracture:
How?
Fatigue failure
Enzyme used to resorb bone.
Acid phosphatase
Wolff's Law
form follows function
Right foot slap
Dec'd strength in right great toe
Sensation diminished over dorsum
Reflexes normal:

Cause?
Dx?
Herniation of fifth lumbar nerve root

Needs MRI of lumbosacral spine
Polyarticular, symmetric stiffness, pain
PIPs, MCPs, wrists swollen
Bumps on elbows

Extra-articular findings?
T-cell involved?
RA:

Ocular inflammation
ILD
Carpal tunnel
Npenia, splenomegaly

NO GN

Th1 involved
TNF-alpha, IL-1:
Role
Stimulate macs
Endothelial cells-->adhesion molecs, VEGF
Hepatocytes-->CRP
Stimulate B synovial cells-->MMPs
Pin in hands, hip, knee
Bumps over DIP:

Pathogenesis
Osteoarthritis--most common form of arthritis, may have been precipitated by prior injury; likely non-inflammatory

Subchondral bone becomes sclerotic, develops cysts
Cartilage becomes soft, fibrillated
Chondrocytes make more preoteoglycan, collegen
Upreg'd MMPs, dec'd TIMPs
Positive birefringence:
Screen for?
Hypothy
Hyperpara
Hemochromatosis
Hypercal
Meniscal cartilage has the potential for healing with ______.
Peripheral tears
What increases risk of osteoarthritis?
Weight gain
Joint malalignment
Age
Muscle atrophy

NOT osteoporosis
This is a feature of ligament tissue in the toe region during a stress strain.
Crimp pattern
A shoulder dislocation is considered what grade of strain?
Grade 3
Role of ACL
Primary stabilizer of knee joint
DMARD associated with retinal toxicity
Hydroxychloroquine
These drugs prevent TNF-alpha from binding.
Enteracept
Infliximab
Cause of death in infant with OI.
Lung hypoplasia
OI involves a defect in collagen type ___.
Type I
Osteitis fibrosa cystica (brown tumor of bone).
Hyperpara
Osteomalacia:
Pathophys
Dec'd mineralization of skeleton due to lack of vitamin D (Adult Ricket's!)
Inactive, postmenopausal women are at risk of ______.
Spinal compression fracture
Avascular necrosis:
Cause
Sickle Cell
Enlarged costochondral junctions forming rosary.
Rickets
Rheumatoid arthritis involves this T cell.
Th1, CD4
Risk factors for gout.
Diuretics, cyclosporine
Renal insufficiency
EtOH
Genes
This arthritis is sytsemic.
Rheumatoid
This arthritis is limited to articular structures.
OA
RA involves Class ___ MHC antigens.
Class II MHC
HLA-DR4
Inc'd risk of RA in white ppl
dsDNA is associated with ____.
Renal disease
SS-A is associated with ______.
Subacute cutaneous lupus
Neonatal lupus
OA:
Pathophys
Inc'd MMPs
Dec'd TIMPs
9:1 male predominance
Iritis, conjunctivitis
Salmonella, chlamydia
Reactive arthritis
HGPRT
If low-->inc'd de novo purine synthesis
This antibody is associated with SLE, but NOT diagnostic.
ANA
This antibody is specific for SLE.
dsDNA
Anti-Smith
Tophi can lead to _____.
Erosion
HLA-B27
**Ankylosing spondylitis**
Psoriatic arthritis
How can OA be distinguished from RA?
Pattern of joint involvement
Extraarthritic features of SLE
Photosens skin rash
Pleuritic chest pain
Oral ulcers
(Arthritis)
SLE is not associated with ______ ethnicity.
Caucasian
Type II collagen is prevalent in _____.
Articular cartilage
What is the smallest bone unit?
Osteon
Oxygen tension is greatest in this growin zone of physis ________.
Proliferative
What tissue has the lowest percentage of water content?
Bone
Women falls and lands on food with knee extended.

What is likely injured?
Tibial plateau
This disorder has normal bone mineralization.
Osteoporosis
This cell type is abnormal in osteopetrosis.
Osteoclast
Most rotator cuff tears are _____.
Atraumatic
What percent of hip fracture patients regain their preinjury ambulatory status?
50%
Physeal fracture in child likely to develop bony bridge that will alter growth and development.
Salter Type IV
Osteoporotic fractures might be best prevented by _____.
Inc'd Ca2+ intake during adolescence
Articular cartilage repair resulting in hyaline-cartilage.
Autologous chondrocyte transplant
Anti-DNA topoisomerase is associated with _______.
Diffuse Scleroderma (PSS)
Anti-histone is associated with ______.
Drug-induced SLE
Anti-Sm is associated with _______.
SLE
Kidney pathology in PSS is secondary to ______.
Fibrosis of vessel walls-->ischemia
How does SLE differ from PSS in dermal deposition?
SLE: liquefactive degeneration of basal epidermis, edema

PSS: Deposition of collagen in dermis, thinning of epidermis
Complement deposition in perimysium.
Dermatomyositis
Mediated by direct T-cell attack.
Polymyositis
Flexion-contraction without joint involvement
PSS
Complement deposition in basement membranes
SLE
Cartilage erosion, eburnated articular surface
OA