Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
What is the mechanism for fatty acid synthesis?
|
Citrate --> citrate shuttle --> Acetyl CoA --> Malonyl CoA --> Fatty Acid
|
|
|
What is the mechanism for fatty acid degradation?
|
Fatty acid + CoA --> Acyl CoA --> Carnitine shuttle --> Acyl CoA -> B-oxidation --> Ketone bodies + TCA cycle
|
|
|
What is the pathology of carnitine deficiency?
|
Inability to transport LCFA's into the mitochondria
|
|
|
What are the symptoms of carnitine deficiency?
|
Weakness, hypotonia, hypoketotic hypoglycemia
|
|
|
What is the rate-limiting step to cholesterol synthesis?
|
HMG-CoA reductase
|
|
|
What inhibits cholesterol synthesis?
|
Statins
|
|
|
What is the function of apolipoprotein E?
|
Mediates remnant uptake
|
|
|
What does apolipoprotein E create?
|
Chylomicron + remnants, VLDL, IDL, HDL
|
|
|
What is the function of apolipoprotein A1?
|
Activates LCAT
|
|
|
What does apolipoprotein A1 create?
|
HDL
|
|
|
What is the function of apolipoprotein C2?
|
Lipoprotein lipase cofactor
|
|
|
What does apolipoprotein C2 create?
|
Chylomicron, VLDL, HDL
|
|
|
What is the function of B48?
|
Mediates chylomicron secretion
|
|
|
What does apolipoprotein B48 create?
|
Chylomicron + remnant
|
|
|
What is the function of apolipoprotein B100?
|
Binds LDL receptor
|
|
|
What dos apolipoprotein B100 create?
|
VLDL, IDL, LDL
|
