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7 Cards in this Set
- Front
- Back
A-131. What are the two types of muscle, their function, and fuel source?
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Type 1: slow, sustained movement - many mitochondria and oxidatize enzymes
Type 2: fast, short duration movements - increased ATPase and glycogen |
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A-131. What is von Girke's Dz, what's missing, where does glycogen build up?
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Type 1 metabolic myopathy
G6P deficient Glycogen build up in the liver |
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A-131. What's lacking in Pompe's Dz and what are the S/S?
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Lysosomal acid maltase deficiency (a-glucosidase)
Glycogen build up in liver, heart, muscle --> cardiomegaly, splenomegaly, muscle hypotonia |
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A-131. Cori's Dz, whats missing and the S/S?
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Deficiency of Amyloglucosidase leading glycogen build up same as Pompes
Stunted growth, hepatomegaly, and hypoglycemia |
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A-131.Pts has glycogen building up in vesicles, in their muscles. What dz is it?
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McArdle's
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A-132. Path, presentation, dx, and tx of Myasthenia Gravis
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Path: auto Abs block post-synaptic ACh receptors
Pres: muscle weakness worse with use Dx: Tensilon screening test (edrophonium give and strenght increases) Tx: Pyridostigmine (anticholinesterase) |
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A-132. How does Lambert-Eaton Syndrome differ from Myes. Gravis?
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ABs towards presynaptic Ca Channels
Sx improve with muscle use and repeated muscle stimulation Exacerbated by Aminoglycosides |