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24 Cards in this Set

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Left supraclavicular node metastasis:
stomach or pancreatic carcinoma
Cat-scratch disease:
due to Bartonella henselae (mixed B and T cell hyperplasia)
Mycosis fungoides:
neoplasm of CD4 Th cells; skin involvement
Burkitt's lymphoma:
EBV relationship with t(8;14). "starry sky"
Diffuse large B-cell lymphoma:
50% of aduls with NHL; elderly and childhood populations. Derives from germinal center. Localized disease with extranodal involvement: GI tract, brain (EBV association with AIDS)
Extranodal marginal zone lymphoma:
Helicobacter pylori gastritis, Low-grade malignant lymphoma of the stomach
Follicular lymphoma:
Derives from germinal center. t(14;18) causing overexpression of BCL2 antiapoptosis gene
Small lymphocytic lymphoma (SLL):
Neoplasm of small, mature B lymphocytes
EBV:
association with mixed cellularity Hodgkin's lymphoma
Lymphocyte predominant:
Asymptomatic young male with cervical or supraclavicular nodal enlargement
Mixed cellularity:
RS cells numerous. increase Eosinophils, plasma cells, histiocytes
Nodular sclerosing:
involves anterior mediastinal nodes and either cervical or supraclavicular nodes. RS cells infrequent. Lacunar cells present. Collagen separates nodular areas.
Nodular sclerosing Hodkin's lymphoma:
anterior mediastinal mass + singe group of nodes above diaphragm
Histiocytes:
CD1 positive; contain Birbeck granules
Plasma cell dyscrasia:
monoclonal spike
MGUS:
Small IgG M spike in elderly patients. No BJ protein
Solitary skeletal plasmacytoma:
vertebra, ribs, pelvis. no BJ protein
Extramedullary plasmacytoma:
upper respitory tract. Absence of malignant plasma cells in the bone marrow. Absence of BJ protein
Lymphoplasmacytic lymphoma (Waldenstrom's macroglobulinemia):
M spike with Igm. BJ protein is present. Generalized lymphadenopathy (not present in myeloma). Anemia and bone marrow (no lytic lesions like myeloma), liver and spleen involvement. Hyperviscosity syndrome due to increased IgM: retinal hemorrhages, strokes, platelet aggregation defects.
Heavy-chain diseases:
M protein heavy chain without light chains. Absence of BJ protein. a-heavy-chain disease, y-heavy-chain disease, m-heavy-chain disease
a-Heavy-chain disease:
neoplastic infiltration of the jejunum
y-Heavy-chain disease:
lymphoma
m-Heavy-chain disease:
associated with chronic lymphocytic leukemia or lymphoma
Hypersplenism:
destruction of hematopoietic cells