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20 Cards in this Set
- Front
- Back
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precapillary sphincter: has SMC? innervated?
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SMC - yes
innervated - no |
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capillary: has SMC? innervated?
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SMC - no
innervated - no |
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venule: SMC? innervatd?
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SMC - yes
innervated - yes! sympathetics |
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diffusion rate is related to:
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surface area, concentration, distance to diffuse
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how do small hydrophilic ions/molecules cross the capillaries?
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via intercellular clefts
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which organs have discontinuous endothelium? continuous?
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discontinuous - liver, spleen, marrow, kidney, intestines, endocrine glands
continuous - CNS, muscle, skin, lung |
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difference between flow limited and diffusion limited exchange?
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flow limited applies to small molecules, in that their diffusion is only limited by the rate of flow
diffusion limited refers to molecules that are too big to diffuse rapidly or if the diffusion distance is far |
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typical plasma mOsmolality:
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280 - 296 mOsm/L
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list the Starling-Landis for Net Filtration Pressure/Rate
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F = K[(Pc + πi) - (Pi + πp)] = Net Filtration Rate (mls/min)
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lung NFP is +1. what does this mean? what is a potential problematic effect? how is it managed?
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positive NFP means fluid will enter interstitial space. pulmonary edema could develop. lungs have adequate lymphatics to manage this.
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why does liver have a relatively low Pc (capillary hydrostatic pressure)?
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it is fed mostly venous blood
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intestine which is digesting will have a ____ NFP?
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negative, i.e. material absorbed into GI interstitial space will enter plasma
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liver has similar πp and πi values. what does this mean? why is this?
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this means there is little oncotic pressure differences, because it is highly fenestrated and permeable to proteins, they approach equilibrium.
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of the organs listed in class, which has the highest lymph flow? lowest?
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highest - kidney
lowest - skeletal mm. |
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of the organs listed in class, which has the highest Pc (capillary hydrostatic pressure)?
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kidney. (glomerulus > peritubular caps)
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what % of filtered plasma returns via absorption/lymph?
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85% via absorption
15% via lymphatics |
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how many ways can protein in the interstitial space return to the circulation?
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only one = lymphatics
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a constricting arteriole will do what to its capillaries regarding filtration/absorption?
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this will reduce Pc (capillary hydrostatic pressure) which will favor absorption from interstitial space into the circulation
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what are 3 "negative feedback" type responses to increased filtration with prevent edema?
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πi decreases, Pi increases, and lymph flow increases
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causes of edema (think starling-landis equation)
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increased Pc (capillary hydrostatic pressure) - CHF and pulmonary edema, right heart failure and leg edema; blocking lymphatics
decreased πp (decreased plasma oncotic pressure) - kidney failure, liver failure - increased loss/decrease production of plasma proteins |
