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8 Cards in this Set
- Front
- Back
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What is the limiting reagent of ethanol metabolism?
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NAD+
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What is fomepizole used for?
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inhibits alcohol dehydrogenase, antidote for methanol or ethylene glycol poisoning
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What is Disulfiram used for?
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Inhibits acetaldehyde dehydrogenase, contributes to hangover symptoms
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What is the pathology of ethanol hypoglycemia?
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Ethanol metabolism increases NADH/NAD+ ratio in the liver, causing diversion of pyruvate to lactate and OAA to malate
Inhibits gluconeogenesis and stimulating fatty acid synthesis |
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What are fatty acids and amino acids converted to in the liver?
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Acetoacetate and B-hydroxybutyrate
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What is diagnostic of excess ketone bodies?
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Breath smells like a fruity odor
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What happens with alcoholism in regard to ketone bodies?
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Excess NADH shunts oxaloacetate to malate
Stalls the TCA cycle, shunts glucose and FFA toward the production of ketone bodies |
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What are ketone bodies made from?
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HMG-CoA
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