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14 Cards in this Set
- Front
- Back
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what is the prototype non-specific alpha adrenergic blocker? what are the effects
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Phentolamine (reversible)
GI stimulation, hypotension, reflexive tachycardia |
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functionally, how is alpha1 adrenergic blocker different than non-specific alpha blockers?
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selective alpha 1 blockers won't block the inhibitor alpha2 channels, so the reflexive tachycardia will be minimal - "expected tachycardia". reflexive tachycardia is excessive when alpha2 is also blocked
thus use prazosin over phentolamine or phenoxybenzamine |
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name the alpha1 adrenergic antagonists?
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Prazosin, Tamsulosin (flomax)
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what is Phenoxybenzamine?
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non-competitive alpha adrenergic receptor blocker, irreversible, cell must make new Receptors to reverse effect
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what autonomic receptors are on pancreatic beta cells? what is the effect?
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alpha1 Rs - trigger less secretion
beta2 Rs - trigger more secretion of insullin |
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compare and contrast the effect of an alpha adrenergic antagonist on Epi and NE
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alpha blockers will reverse Epi's increased BP
alpha blockers simply diminish NE's effects on BP |
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what drugs lead to postural hypotension? what is that?
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postural hypotension is a loss of BP upon standing
alpha blockers (alpha1) leads to this |
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suffix of beta blockers?
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-olol
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classic non-selective beta blocker?
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propranolol
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regarding glaucoma, the main beta blocker used?
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timolol
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you want to use a beta blocker for hypertension, but patient has asthma. Rx:
why? |
metoprolol or atenolol.
-specific beta1 blockers |
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after prolonged treatment with a beta blocker, what might happen with rapid removal of the drug?
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possible MI, as beta receptors will be upregulated in response to beta-blocker. the NE/Epi stimulation will cause a rapid increase in heart's demand for O2 and can lead to an MI
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Rx beta-blockers is risky if patients have ____
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diabetes (beta blocker reduces insulin secretion)
asthma - beta2 block will bronchoconstrict Heart Failure |
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describe the gamut of glaucoma treatment options
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REDUCE SYNTHESIS
alpha agonist beta blocker (timolol) diuretics INCREASE OUTFLOW muscarinic agonist (Pilocarpine) Latanoprost (PGF2a) Chronic - use beta blocker ER - Pilocarpine, surgery |
