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16 Cards in this Set
- Front
- Back
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What are the sx of multiple sclerosis?
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diplopia, optic neuritis, urge incontinence (detrusor hyperreflexia), vertigo, weakness of muscle +/- paresis, sensory disturbances
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What are the plaques in white matter in MS?
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area of myelin breakdown with presence of abundant lipid-laden macrophages (called microglial cells)
white matter looks like gray matter |
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What is adrenoleukodystrophy?
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peroxismal enzyme deficiency in beta-oxidation of FAs (very long chain fatty acids)
results in neuropathy and adrenal insufficiency |
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What sphingolipidosis leads to demyelination of CNS and peripheral nervous system?
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metachromatic leukodystrophy
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The JC virus causes progressive multifocal leukoencephalopathy that results in what pathology?
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complete destruction of all oligodendrocytes
only occurs in severe immunosuppression |
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This alcoholic mediated CNS disorder results from macrophage accumulation at hemorrhages sites and subsequent development of open cysts in brain lines with hemosiderin-laden macrophages.
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Korsakoff's encephalopathy
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What are the sx of prolactinoma?
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amenorrhea, impotence, galactorrhea, gynecomastia, visual complaints
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SIADH results in what signs and sx?
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dilutional hyponatremia,
cerbral edema (with neurologic dysfunction), +/- HTN |
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This disorder is caused by ADH deficiency secondary to decreased secretion by the posterior pituitary.
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central DI
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What is Conn's syndrome?
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hyperaldosteronism d/t adrenal adenoma
HTN, hypokalemia |
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Pheochromocytoma is associated with what 2 syndromes?
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MEN IIa/IIIb
von Hippel-Lindau |
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What is Addison's disease?
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hypoaldosteronism
hypotension weakness difuse hyperpigmentation |
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What TSH levels are seen in sick euthyroid s/d?
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ALL have normal TSH
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What is the MCC of painful thyroid?
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DeQuervain's thyroiditis (sub-acute thyroiditis)
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What is Plummer's dz?
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multi-nodular thyroid goiter that occurs in post-menopausal, multiparous females
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What categories of thyroidism have high T3 resin uptake?
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1 and 2dary hyperthyroidism
factitious hyperthyroidism struma ovarii subacute thyroidits (also can be low uptake) |
