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15 Cards in this Set

  • Front
  • Back
3 factors affecting distribution are?,?,?
blood flow
solubility
protein binding
When a drug binds to a protein they become ? The #1 protein in blood is ? So if a drug is highly protein bound it will have ? of an effect in the body.
inactive
Albumin
less
Drugs that are highly protein bound take a ? time to work and this makes them difficult to ? and we can ? the patient because we haven't seen its affect.
longer

regulate

overdose
Highly protein bound drugs are ? in duration and they can be ? to a patient.
longer

toxic
name 4 highly protein bound drugs?
Coumadin 2-3days
Thyroid 1 week
Digoxin 2-3 days
Alleve
The first part of MADE is ? , another way that drugs are pharmacokinetically affected in the body.
Metabolism
Parts of the body where drugs are metabolized are LLIMPK?
Liver, lungs, intestines, muscle, plasma, kidneys
Name factors affecting metabolism?
Disease
Genetics
Environment
Age
Metabolism is changing drugs into ? metabolites/?-transformation to be ?
inactive/bio
excreted
Almost all drugs are metabolized by the ?
liver
A drug's ? is the time it takes for its plasma concentration to drop to half its original value/be eliminated.
half-life
Factors affecting 1/2 life are ?
absorption
metabolism
excretion
We need to know a drugs 1/2 life so we know ?
how much drug to give and when to give it
It take drugs 4-5 half lives to get maximum ? value
therapeutic
A long 1/2 life for a drug can make it ? toxic and ? to control.
highly
difficult