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15 Cards in this Set
- Front
- Back
3 factors affecting distribution are?,?,?
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blood flow
solubility protein binding |
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When a drug binds to a protein they become ? The #1 protein in blood is ? So if a drug is highly protein bound it will have ? of an effect in the body.
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inactive
Albumin less |
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Drugs that are highly protein bound take a ? time to work and this makes them difficult to ? and we can ? the patient because we haven't seen its affect.
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longer
regulate overdose |
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Highly protein bound drugs are ? in duration and they can be ? to a patient.
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longer
toxic |
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name 4 highly protein bound drugs?
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Coumadin 2-3days
Thyroid 1 week Digoxin 2-3 days Alleve |
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The first part of MADE is ? , another way that drugs are pharmacokinetically affected in the body.
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Metabolism
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Parts of the body where drugs are metabolized are LLIMPK?
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Liver, lungs, intestines, muscle, plasma, kidneys
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Name factors affecting metabolism?
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Disease
Genetics Environment Age |
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Metabolism is changing drugs into ? metabolites/?-transformation to be ?
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inactive/bio
excreted |
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Almost all drugs are metabolized by the ?
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liver
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A drug's ? is the time it takes for its plasma concentration to drop to half its original value/be eliminated.
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half-life
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Factors affecting 1/2 life are ?
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absorption
metabolism excretion |
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We need to know a drugs 1/2 life so we know ?
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how much drug to give and when to give it
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It take drugs 4-5 half lives to get maximum ? value
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therapeutic
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A long 1/2 life for a drug can make it ? toxic and ? to control.
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highly
difficult |