Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
Where is Type 1 collagen found?
|
90%, most common, strongest
Found in Bone, skin, tendons |
|
|
Where is Type 2 collagen found?
|
Cartilage, vitreous body, nucleus pulposus
|
|
|
Where is Type 3 collagen found?
|
Reticulin, skin, BV's, uterus, fetal tissue, granulation tissue
|
|
|
Where is type 4 collagen found?
|
Basement membrane
|
|
|
Where does synthesis of collagen take place?
|
RER
|
|
|
What is the first step of collagen synthesis?
|
Translocation of collagen alpha chains (preprocollagen) usually glycine-XY
|
|
|
Where does the second step of collagen synthesis take place?
|
ER
|
|
|
What is the second step of collagen synthesis?
|
Hydroxylation of specific proline and lysine residues (requires Vitamin C)
|
|
|
Where does the third step of collagen synthesis take place?
|
ER
|
|
|
What is the third step of collagen synthesis?
|
Glycosylation of pro-a-chain hydroxylysine residues and formation of procollagen via hydrogen and disulfide bonds
|
|
|
What is the fourth step of collagen synthesis?
|
Exocytosis of procollagen into extracellular space
|
|
|
What is the fifth step of collagen synthesis?
|
Proteolytic processing
Cleavage of disulfide-rich terminal regions of procollagen --> transformation into tropocollagen |
|
|
What is the 6th step of collagen synthesis?
|
Cross-linking
Reinforcement of many staggered tropocollagen molecules by covalent lysine-hydroxylysine cross linkage |
