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37 Cards in this Set
- Front
- Back
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Agonist
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bind with receptor for therapeutic effect
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Antagonist
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bind with receptor to prevent actions of agonist
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pharmacodynamics
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absorption, distribution, metabolism, and excretion
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absorption
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process of getting drug into the blood stream/body
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distribution
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transport of drug through the body to the site of action
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metabolism
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how drug is changed chemically to facilitate excretion
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excretion
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how drug leaves the body
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therapeutic index
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range of drug dosage that causes desired effect in body
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low index
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narrow margin of safty
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high index
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wide margin of safety
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peak drug level
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highest plasma concentrations @ a specific time
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trough level
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lowest plasma concentration @ a specific time
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loading dose
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large initial dose given to quickly raise plasma concentrations
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maintenance dose
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the amount of the drug prescribed to maintain a therapeutic level on a daily basis
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synergist
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effect greater than both drugs sum (potentiates the effect) 1+1=>2
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additive
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combination of 2 drugs = efcect is doubled
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antagonist
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one drug interferes with the action of another, diminishes or neutralizes
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allergic reaction
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antigen antibody reaction with release of histamine
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drug idiosyncracy
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(unpredictable) usually abnormal reaction
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drug tolerance
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decrease response to the drug-requires a larger dose for the same action
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cumulation
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body can't metabolize the whole dose, build up, s&s of overdose
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toxic reactions
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negative effect from too much drug
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side effects
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known action that canoccur other than desired effect
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teratogenic
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action causing defects during fetal development
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polypharmacy
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large number of drugs taken by one patient 7+
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legend (caution) drugs
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drugs that are not included in the CSA
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immunity
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body;s ablility to identify and protect itself against microorganisms that are potentially harmful
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humoral immunity
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process of creating antibodies by the lymphocythes
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cell-mediated immunity
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results of activity of T-lymphocytes
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active immunity
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there is a response, body forms antibodies
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naturally acquired active immunity
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get the disease and body makes antibodies in response to the dsease
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artificaially acquired active immunity
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body makes antibodies in response to an injected antigen (vaccine or toxin)
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passive immunity
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this is a gift of antibodies given to you
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naturally acquired passive immunity
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antibodies passed across the placenta
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artificially acquired passive immunity
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injection of antibodies for temporary protection
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attenuated antigen
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weakened live microorganism
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dead antigen
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contains proteins of microorganism
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