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17 Cards in this Set
- Front
- Back
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What are the three estrogen drugs?
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Ethinyl Estradiol, DES, Mestranol
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When are the estrogen drugs used?
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Hypogonadism or ovarian failure, menstrual abnormalities, HRT in post-menopausal women
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When do you use estrogen for men?
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Men with androgen dependent prostate cancer
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What is the risk with estrogen therapy?
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Can cause inc risk of endometrial cancer and increase risk of thrombi
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What are the two contraindications of estrogen therapy?
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ER(+) breast cancer
Hx of DVT |
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What are the 3 SERM's?
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Clomiphene, Tamoxifen, Raloxifen
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What is the mechanism for the Clomiphene?
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Partial agonist at estrogen receptors in hypothalamus, prevents normal feedback inhibition and increases release of LH and FSH from pituitary
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When are the Clomiphene used?
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Used to treat infertility and polycystic ovarian syndrome
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What may happen with clomiphene use?
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multiple simultaneous pregnancies
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What is tamoxifen used for?
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Antagonist on breast tissue, used to treat and prevent recurrence of ER(+) breast cancer
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What is raloxifene used for?
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Agonist on bone, reduces resorption of bone, used to treat osteoporosis
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When is hormone replacement therapy used?
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To treat or prevent menopausal symptoms and osteoporosis
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What is the danger of using HRT?
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Inc risk of endometrial cancer
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What are progestins used for?
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Oral contraceptives and in the treatment of endometrial cancer and abnormal uterine bleeding
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What is Mifepristone used for?
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Terminates pregnancies
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What is the mechanism for Mifepristone?
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Inhibitor of progestins at progesterone receptors
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What is the mechanism for oral contraceptives?
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Estrogen and progestins inhibit LH/FSH, preventing estrogen surge --> prevents LH surge
Progestins cause thickening of cervical mucus, limiting access of sperm to uterus Progestins also inhibit endometrial proliferation |
