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32 Cards in this Set
- Front
- Back
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Advantages of solid dosage forms (4)
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1. Stable (compared to liquid and semi-solid)
2. Accurate in dose 3. Compact (easy to carry) 4. Simple to make (except for inhalation) |
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Disadvantages of solid dosage forms (2)
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Not easy to make for inhalation
Not suitable for certain routes |
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all solid dosage forms come from
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powder
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2 uses of powders
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1. pharmaceutical preparation
2. raw materials |
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granule AKA
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pellet
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granule/pellet
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agglomerate of small particles
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agglomerate of small particles
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granule/pellet
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3 methods for making granules/pellets
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wet/dry granulation
extrusion/spheronization spray drying |
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capsules
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shell: hard/soft gelatin or other polymers
content: solid/liquid/semi-solid |
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parts of a hard capsule
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cap
body seal |
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how are tablets normally prepared
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compression
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what do tablets need that other solid forms may not
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complex formulations
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which solid dosage form requires complex formulation
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tablet
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order of bioavailability of oral solid dosage forms (most to least) (4)
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powder
granules hard capsules tablets |
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what determines bioavailability
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dissolution rate if dissolution is the rate limiting step in drug absorption
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when should particles and powders be analyzed
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preformulation (before a formulation is designed)
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which properties are important
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particle and powder properties
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why are they important
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product quality --> therapeutic effect
ex. tube feeding |
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major complication with nasogastric tube feeding
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obstruction of the tube
orifice size determines what particles can go through |
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particle size and lung distribution
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>5um: particles deposit in mouth and throat, airways (impaction)
1-5 um: particles make it to alveolar region (gravity) <0.5um: particles are exhaled (diffusion) |
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particle properties
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size
shape density porosity |
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powder properties
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density
porosity flowability wettability compressibility |
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particle size and dissolution rate
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larger particles dissolve more slowly
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particle size and bioavailability
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larger particles dissolve more slowly --> lower F
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large or small particles flow better
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large
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large or small particles have better compressibility
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large
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large or small particles (and what size exactly) is better for suspension
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small (0.5-10 microns)
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large or small particles (and what size exactly) is better for non-grittiness
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small (50-100 microns)
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when do you want non-grittiness
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ointments
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what is the word for the property of getting into the lungs
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penetratability
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large or small particles (and what size exactly) is better for penetratability
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small (1-5 microns)
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x
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x
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