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20 Cards in this Set
- Front
- Back
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P contains ____ diclofenac sodium solution
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1.5%
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P contains _____ w/w dimethyl sulfoxide
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45.5%
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DMSO increased penetration in a Franz Chamber by _____% at 24 hr and by _____% at 48hrs.
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525, 750
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P has been studied in more the ______ patients.
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2100
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P is supported by ____ efficiacy trials.
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5
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Compared to Diclofenac, P's plasma concentration was_____. The systemic exposure is ____ of oral Diclofenac.
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Less then 1%, 1/125
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The P GI adverse event profile was shown to be ______
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tolerable
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In an open-label, 12 mth, long-term safety and tolerability study, only ____ of patients withdrew due to digestive AEs
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1%
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1 bottle of P = ____ mo, for 1 knee
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1
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____ tubes of Voltaren Gel = 1 mo, for 1 knee
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5
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P dries in _____
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10 min
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What can you say about P's efficacy vs ODiclo
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Comparable or similar
NOT the same |
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How many patients has P been studied in (based on the published studies)
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2100
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Time to shower/ bathe after P application?
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30 mins
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Time to shower/bathe after VGel application
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60 min
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P has shown to _______ unlike VGel
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Improve physical function
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In the Franz Chamber study, P showed a ______ % increase in Diclofenac penetration at 24 and _____% increase at 48 hrs
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525 and 750
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Although NSAIDs have been shown to inhibit platelet aggregation, P had _____ effect?
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no
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How do you write a Rx for P
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P
# 2 bottles 40 gtts to each knee as directed QID with 3 refills |
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How would you address a HCPs concern about dry skin?
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Ack: DMSO is a solvent and it makes sense that it would dry out the skin, but unlike the clinical trials patients can use a lotion etc to treat it
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