1. INTRODUCTION
Warfarin is a most common Anticoagulant in prevention and treatment of thromboembolic events despite the availability of new drugs such as Novel Oral Anticoagulants due to its affordability. The establishment of the International Normalized Ratio (INR) helps to guide the dosing requirement for patients receiving the warfarin therapy. However, over-anticoagulation leads to adverse events such as haemorrhage while thromboembolic events can happen even at a recommended dose.
Different INR is based on different treatment. For example, for patients with atrial fibrillation, it is recommended that the INR range is 2.0-3.0, as the incidence of both haemorrhagic or thromboembolic events are the lowest. However, various studies have reported that Asian population are more sensitive to warfarin than …show more content…
However, such recommendations were only validated for western populations and the study has reported that Asian subjects are more sensitive to warfarin than westerners. Results obtained from the study have shown that Hong Kong Chinese patients receiving warfarin therapy have the lowest risk of major bleeding or thromboembolic events at an INR of 1.8 to 2.4.
This study was supported by another findings conducted by Wang & Chiang (2013). It reported that the incidence of major bleeding in Asians was higher as compared to non-Asians. The study believed that Asians are more sensitive to warfarin and are prone to bleeding. Wang & Chiang (2013) also suggested that most of the Asian studies indicated an increased risk of major bleeding at much lower INR at 2.3 or higher for the use of warfarin in Asians. The study concluded that the best target for the prevention of thromboembolism for Asian and Japanese was at an INR of 1.6 to
Warfarin is a most common Anticoagulant in prevention and treatment of thromboembolic events despite the availability of new drugs such as Novel Oral Anticoagulants due to its affordability. The establishment of the International Normalized Ratio (INR) helps to guide the dosing requirement for patients receiving the warfarin therapy. However, over-anticoagulation leads to adverse events such as haemorrhage while thromboembolic events can happen even at a recommended dose.
Different INR is based on different treatment. For example, for patients with atrial fibrillation, it is recommended that the INR range is 2.0-3.0, as the incidence of both haemorrhagic or thromboembolic events are the lowest. However, various studies have reported that Asian population are more sensitive to warfarin than …show more content…
However, such recommendations were only validated for western populations and the study has reported that Asian subjects are more sensitive to warfarin than westerners. Results obtained from the study have shown that Hong Kong Chinese patients receiving warfarin therapy have the lowest risk of major bleeding or thromboembolic events at an INR of 1.8 to 2.4.
This study was supported by another findings conducted by Wang & Chiang (2013). It reported that the incidence of major bleeding in Asians was higher as compared to non-Asians. The study believed that Asians are more sensitive to warfarin and are prone to bleeding. Wang & Chiang (2013) also suggested that most of the Asian studies indicated an increased risk of major bleeding at much lower INR at 2.3 or higher for the use of warfarin in Asians. The study concluded that the best target for the prevention of thromboembolism for Asian and Japanese was at an INR of 1.6 to