Type 2 Diabetes and Adiponectin
The endocrine system is a collection of glands which secretes chemical messengers such as hormones directly into the bloodstream to create a response in a target cell (Reece,M et al. 2011). Adipose tissue is a major organ in the endocrine system which stores energy and produces active peptides called adipocytokines. Adiponectin is a hormone from the adipose tissue and which is encoded by the gene ADIPOQ. It breaks down fatty acids and regulates glucose levels in our bodies. Therefore, low levels of adiponectin can lead to obesity, type II diabetes and metabolic syndrome. A single nucleotide polymorphism (SNP) is a sequence of DNA which varies within a population with various factors that predispose diseases (Bermudez,V …show more content…
Recently reports has shown that there is however no association of SNPs with ADIPOR1 to type II diabetes in residents of Japan, United Kingdom, France and North America (African Americans). However, research has shown that there is an association between SNPs with ADIPOR2 and diabetes in the French population. Moreover, research states that SNPs of ADIPOR2 are responsible for the development of diabetes. Nevertheless, it is unsure of whether the variance of the results is due to the individuals’ genetic background, their exposure to different environmental factor or whether there was some variations in the statistics (Bermudez,V et al. …show more content…
Study two shows that they do not relate to insulin resistance. Study 2 analyses the insulin sensitivity levels that are affected by AdipoR1 and AdipoR2 and how they are affected by the age and racial features of a study cohort (Peters, K et al. 2013). Study 2 does not discuss the SNPs’ links to type 2 diabetes in detail and their findings do not correlate many other studies undertaken. Study 1 however coincides a number of other previous research studies and more importantly, identified 5 SNPs in total that are associated with insulin resistance which leads to type 2 diabetes. The 2nd research study did not focus on the SNPs identified by the former and this may have been the reason for the conclusions made. Results presented therefore make contradicting arguments and this is encouraging more research on this area and therefore it leads to overall improvement of the
The endocrine system is a collection of glands which secretes chemical messengers such as hormones directly into the bloodstream to create a response in a target cell (Reece,M et al. 2011). Adipose tissue is a major organ in the endocrine system which stores energy and produces active peptides called adipocytokines. Adiponectin is a hormone from the adipose tissue and which is encoded by the gene ADIPOQ. It breaks down fatty acids and regulates glucose levels in our bodies. Therefore, low levels of adiponectin can lead to obesity, type II diabetes and metabolic syndrome. A single nucleotide polymorphism (SNP) is a sequence of DNA which varies within a population with various factors that predispose diseases (Bermudez,V …show more content…
Recently reports has shown that there is however no association of SNPs with ADIPOR1 to type II diabetes in residents of Japan, United Kingdom, France and North America (African Americans). However, research has shown that there is an association between SNPs with ADIPOR2 and diabetes in the French population. Moreover, research states that SNPs of ADIPOR2 are responsible for the development of diabetes. Nevertheless, it is unsure of whether the variance of the results is due to the individuals’ genetic background, their exposure to different environmental factor or whether there was some variations in the statistics (Bermudez,V et al. …show more content…
Study two shows that they do not relate to insulin resistance. Study 2 analyses the insulin sensitivity levels that are affected by AdipoR1 and AdipoR2 and how they are affected by the age and racial features of a study cohort (Peters, K et al. 2013). Study 2 does not discuss the SNPs’ links to type 2 diabetes in detail and their findings do not correlate many other studies undertaken. Study 1 however coincides a number of other previous research studies and more importantly, identified 5 SNPs in total that are associated with insulin resistance which leads to type 2 diabetes. The 2nd research study did not focus on the SNPs identified by the former and this may have been the reason for the conclusions made. Results presented therefore make contradicting arguments and this is encouraging more research on this area and therefore it leads to overall improvement of the