According to each age group, there were four sero-positive cases in children (with age group between 9 and ≤ 12 years); two cases in adolescents (with age group between 12 and ≤ 16 years) and two cases in adults (with age group 16-21 years). Intestinal manifestations, chronic diarrhea, recurrent abdominal pain/ distension, recurrent aphtha's stomatitis, anemia and bleeding tendency were significantly more common in sero-positive cases (P=0.001, 0.001, 0.016, 0.00, 0.001and 0.04 respectively). All sero-positive cases (100%) had lower BMIs than normal. There were no correlations between the tTG antibodies levels and HbA1c levels. Conclusions: The presence of tTG IgA antibodies is associated with significant changes in the clinical status of patient with type-1 DM. Celiac disease related manifestations like weight loss; anemia and chronic diarrhea were more common in sero-positive diabetic patients. Serological screening for CD should be performed in all patients with type-1DM for early diagnosis and prevention
According to each age group, there were four sero-positive cases in children (with age group between 9 and ≤ 12 years); two cases in adolescents (with age group between 12 and ≤ 16 years) and two cases in adults (with age group 16-21 years). Intestinal manifestations, chronic diarrhea, recurrent abdominal pain/ distension, recurrent aphtha's stomatitis, anemia and bleeding tendency were significantly more common in sero-positive cases (P=0.001, 0.001, 0.016, 0.00, 0.001and 0.04 respectively). All sero-positive cases (100%) had lower BMIs than normal. There were no correlations between the tTG antibodies levels and HbA1c levels. Conclusions: The presence of tTG IgA antibodies is associated with significant changes in the clinical status of patient with type-1 DM. Celiac disease related manifestations like weight loss; anemia and chronic diarrhea were more common in sero-positive diabetic patients. Serological screening for CD should be performed in all patients with type-1DM for early diagnosis and prevention