Triiodothyronine Research Paper

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Triiodothyronine, with a chemical name of 3,3',5-Triiodothyronine (T3), is one of four thyroid hormones that exhibit biological activity, and contains 3 iodines and 2 tyrosine’s, as seen in Fig. 1. 20 % of T3 is formed from the amino acid tyrosine within specific follicle cells of the thyroid gland by the oxidative condensation of its biological precursors, monoiodotyrosine and diiodotyrosine, and is then subsequently secreted into the bloodstream. The remaining 80% is produced from the conversion of thyroxine (T4) into triiodothyronine (T3), by removal of the iodine atom from the carbon atom number five of the outer ring of T4, as seen in Fig. 2. T4 is deiodinated in peripheral tissues to form T3 due to T3’s greater potency on target tissues

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