The paper I chose for the Case of the Term assignment is “A case of tolterodine poisoning”. Tolterodine (Detrol, Detrusitol) (CAS #124937-51-5) is an antimuscarinic drug that belongs to the class of drugs known as antispasmodics. Tolterodine is prescribed to treat urinary incontinence or overactive bladder by relaxing the muscles in the bladder. Tolterodine is marketed and manufactured by Pfizer. Antimuscarinic drugs inhibit the action of acetylcholine at muscarinic receptors. Tolterodine acts on the M2 and M3 receptors and targets the bladder more than other parts of the body; therefore, only small amount of drug is needed to treat the condition and thus causing fewer side effects. The paper discusses a report of an 82-year-old man who was
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The patient was described as confused and had ingested 182 tolterodine pills. Tolterodine prescribed for the patient was an immediate-release (IR), twice-daily, tablet formulation where each tablet contains 2mg of tolterodine tartrate. Patient had the following symptoms: “blood pressure at 175/80 mmHg, pulse rate at 82 beats per minute, Glasgow Coma Scale score was 13/15 (E4V4M5), body temperature was 38.3 degrees Celsius (tympanic), respiratory rate was 10 breaths per minute and oxygen saturation by pulse oximetry was 96% while he was put on oxygen through a non-rebreathing mask, chest auscultation was clear, abdominal examination revealed hypoactive bowel sound, pupils were 5 mm with sluggish response to light, palpation of the axillary skin showed it was dry, bedside glucose test was 6.8 mmol/L, electrocardiogram showed sinus rhythm, QTc by calculation using Bazett's formula was 462 ms, chest and abdominal X-rays were unremarkable, point-of-care tests of electrolytes and acid-base status were
The patient was described as confused and had ingested 182 tolterodine pills. Tolterodine prescribed for the patient was an immediate-release (IR), twice-daily, tablet formulation where each tablet contains 2mg of tolterodine tartrate. Patient had the following symptoms: “blood pressure at 175/80 mmHg, pulse rate at 82 beats per minute, Glasgow Coma Scale score was 13/15 (E4V4M5), body temperature was 38.3 degrees Celsius (tympanic), respiratory rate was 10 breaths per minute and oxygen saturation by pulse oximetry was 96% while he was put on oxygen through a non-rebreathing mask, chest auscultation was clear, abdominal examination revealed hypoactive bowel sound, pupils were 5 mm with sluggish response to light, palpation of the axillary skin showed it was dry, bedside glucose test was 6.8 mmol/L, electrocardiogram showed sinus rhythm, QTc by calculation using Bazett's formula was 462 ms, chest and abdominal X-rays were unremarkable, point-of-care tests of electrolytes and acid-base status were