With Gordon taking such a high dose of diazepam, it seems reasonable to conclude that she had developed some tolerance to the drug. Tolerance is defined by the National Institute on Drug Addiction as a state in which an organism no longer responds to a drug, or alternatively as requiring a higher dose to achieve the same initial response level (NIDA, 2007). Tolerance to benzodiazepines tend to develop at varying rates and degrees, and not all forms of tolerance have negative outcomes. For example, tolerance to the hypnotic effects of diazepam tends to develop quickly, which can be beneficial in the treatment of anxiety. In contrast, tolerance to the anxiolytic effects of the drug occurs more slowly, with a gradual loss in efficacy. Due to
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Evidence-based pharmacotherapy of Generalized Anxiety Disorder. Int J Neuropsychopharmacol 8: 293-302.
Davies M (2003). The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci 28: 263-274.
Dell’osso B, Lader M (2011) Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders? A critical reappraisal. Eur Psychiatry 28: 7-20
Griffin C, Kaye A, Bueno F, Kaye A (2013). Benzodiazepine Pharmacology and Central Nervous System–Mediated Effects. Ochsner J 13: 214-223.
Herzberg D (2006). “The Pill You Love Can Turn on You”: Feminism, Tranquilizers, and the Valium Panic of the 1970s. Am Q 58: 79-103.
Kangilaski, J (1976). Federal Agency Lists Most Widely Abused Drugs. AMA J Ethics 236: 432
Longo L. and Johnson B (2000). Addiction: Part I. Benzodiazepines--Side Effects, Abuse Risk and Alternatives. Am Fam Physician 61: 1-11.
Marshall K, Georgievskava Z, Georgievsky I (2009). Social reactions to Valium and Prozac: A cultural lag perspective of drug diffusion and adoption. Res Social Adm Pharm 5: 94-107.
Mehdi T (2012). Benzodiazepines Revisited. Br J Med Pract 5: …show more content…
Principles of Drug Addiction Treatment, 3rd edn. U.S. Department of Health and Human Services: Maryland, MD.
National Institute on Drug Abuse (2007). The Neurobiology of Drug Addiction. U.S. Department of Health and Human Services: Maryland, MD.
O'Brien C (2005). Benzodiazepine Use, Abuse and Dependence. J Clin Psychiatry 66: 28-33.
Lader M, Russell J (1993). Guidelines for the prevention and treatment of benzodiazepine dependence: summary of a report from the Mental Health Foundation. Addiction 88: 1707-1708.
Rowlett J, Platt D, Lelas S, Atack J, Dawson G (2005). Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Scie 102: 915-920.
Sternbach L (1979). The Benzodiazepine Story. J Med Chem. 22:
Evidence-based pharmacotherapy of Generalized Anxiety Disorder. Int J Neuropsychopharmacol 8: 293-302.
Davies M (2003). The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci 28: 263-274.
Dell’osso B, Lader M (2011) Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders? A critical reappraisal. Eur Psychiatry 28: 7-20
Griffin C, Kaye A, Bueno F, Kaye A (2013). Benzodiazepine Pharmacology and Central Nervous System–Mediated Effects. Ochsner J 13: 214-223.
Herzberg D (2006). “The Pill You Love Can Turn on You”: Feminism, Tranquilizers, and the Valium Panic of the 1970s. Am Q 58: 79-103.
Kangilaski, J (1976). Federal Agency Lists Most Widely Abused Drugs. AMA J Ethics 236: 432
Longo L. and Johnson B (2000). Addiction: Part I. Benzodiazepines--Side Effects, Abuse Risk and Alternatives. Am Fam Physician 61: 1-11.
Marshall K, Georgievskava Z, Georgievsky I (2009). Social reactions to Valium and Prozac: A cultural lag perspective of drug diffusion and adoption. Res Social Adm Pharm 5: 94-107.
Mehdi T (2012). Benzodiazepines Revisited. Br J Med Pract 5: …show more content…
Principles of Drug Addiction Treatment, 3rd edn. U.S. Department of Health and Human Services: Maryland, MD.
National Institute on Drug Abuse (2007). The Neurobiology of Drug Addiction. U.S. Department of Health and Human Services: Maryland, MD.
O'Brien C (2005). Benzodiazepine Use, Abuse and Dependence. J Clin Psychiatry 66: 28-33.
Lader M, Russell J (1993). Guidelines for the prevention and treatment of benzodiazepine dependence: summary of a report from the Mental Health Foundation. Addiction 88: 1707-1708.
Rowlett J, Platt D, Lelas S, Atack J, Dawson G (2005). Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Scie 102: 915-920.
Sternbach L (1979). The Benzodiazepine Story. J Med Chem. 22: