It is hypothesized that motor proteins, dynein and kinesin control the transport of melanosomes into melanocyte dendrites as it is the net sum of cytoskeletal forces on an organelle that regulate intracellular transport. Dynein typically walk towards the minus-end of a microtubule in retrograde transport while kinesin move towards the plus-end in anterograde transport in neurons. The purpose of the article was to determine the role and effect of cytoplasmic dynein in melanosome transport in human melanocytes (1). Located in the basal layer of the epidermis, melanocytes produce melanin by inserting granules of melanin into melanosomes (2). Melanosomes are the site of synthesis, storage, and transport of melanin pigments that reside in the matrix…
In order to assist the provider in educating on all the relevant information, the author suggests the use of three fact sheets developed by the Melanoma Research Foundation (see Appendix D, E, F). The first fact sheet titled Melanoma Fact Sheet provides information on risk factors for melanoma and the interventions that can be used to reduce the risk of developing the disease (see Appendix D). The second fact sheet titled ABCDEs of Melanoma provides information on how to identify suspicious moles (see Appendix E). The third fact sheet titled Guide to Self Screening provides information on the correct way to perform a SSE (see Appendix F). After the provider discusses the three facts sheets, the patient can take the resources home.…
Malignant Melanoma Melanoma is caused mainly from the intense exposure of UV radiation from the sun. Melanoma starts in the epidermis and stratum Basale layers. The UV rays will eventually cause the DNA replications which will make the cells replicate very fast making the cancer tumors. When treated early it is most of the time solved and doesn’t come back. When the early melonoma is not treated it will soon turn into malignant melonoma and will spread around the body to many vital organs.…
Malignant melanoma is a form of skin cancer that forms in melanocyte cells in the basal layer of the epidermis which produce melanin that gives human their skin, hair, and eye color. Malignant melanoma grows malignant tumors due to DNA damage to the skin cells probable to UV radiation that causes mutations and sets off skin cells to multiply rapidly and form these malignant tumors. Melanomas are closely similar to moles making it difficult for a person to distinguish from a normal mole to a malignant mole or melanoma. Most melanomas are black or brown in color, but some can also be pink, red, purple, blue, or even white. Melanoma has 5 stages, stage 0 and 1 being localized; stage 0 is noninvasive while stage one has invaded the skin…
The most famous type of skin cancer is melanoma. Melanoma is most dangerous skin cancer and accounts for death each year. This statement alone should change every parents view.…
Cancer, the dreaded six letter word that will affect almost everyone at some point in their life; whether cancer is their cancer or the cancer of a loved one. What happens when the cancer the doctors said was gone comes back only a year later and this time worse than before? For Mary Williams, this just so happened to be her case. Her malignant melanoma is back and this time an unspoken terminal is present in the diagnosis. As a mother of two young girls, eight and eleven years old, Williams is given no choice but to fight.…
Melanoma is a type of cancer that is considered one among the most dangerous. Melanoma traces are usually found over the skin, but rarely it can even be found in the eye or even in the internal organs. The main cause of Melanoma is the direct exposure to the ultraviolent (UV) rays. Reducing tanning from sun or from tanning lamps can curtail the chance from Melanoma. For past decades, recovery from Melanoma was a nightmare.…
The American Cancer Society estimates that skin cancer is the most prevalent of all cancers with over 2 million cases of non-melanoma skin cancer each year and 75,000 melanoma cases in 2012**. Melanoma is one of themost serious consequences of skin cancer where melanocytesproliferate actively with enhanced accumulation of melaninpigment leading to hyperpigmentation and tumor formation. Up-regulated levels oftyrosinase enzyme appear to be correlated to with greater production and accumulation of melanin which induces skin cancer. Tyrosinase (EC 1.14.18.1) is an oxygen oxidoreductase enzyme involved in vertebrate cutaneous pigmentation, browning of fruits and vegetables, and morphogenesis and fruiting body formation in fungi.…
Melanoma is the most lethal form of skin cancer caused when skin is exposed to intense UV rays. Estimates suggests that the deaths tolls are more than 50,000 with 3 million and more reports of it yearly. However, early diagnosis of malignant melanoma significantly curbs the mortality rate. Several computer-aided diagnosis systems have been proposed in assisting detection of malignant melanoma in its earlier stages. These systems help in early detection and earlier diagnosis of many symptoms which results in better and accurate treatment.…
Sun is the essential part of our life. It helps regulate the climate and it is the main source of energy in the ecosystems. If just one of these factors changed markedly, it would impact all life on Earth. Furthermore, sunlight also helps our bodies to form vitamin D underneath the skin. This vitamin helps people to build and maintain bones.…
It looks like a shiny bump and is highly treatable because it is only present on the top layer of the skin (Leonard 20). Squamous cell carcinoma appears on or near the face (Leonard 20). This isn’t a very common form of skin cancer but is treatable (Leonard 20). At the Dana Farber Cancer Institute, the world leader in adult and pediatric cancer treatment and research, there are 10- 20 new cases of melanoma each week (Salsberg). This number sounds small compared to the 65,000 new cases each week nationwide…
Malignant melanocytes, the cells found between the dermis and epidermis that produce for skin pigmentation, proliferate uncontrollably and accumulate into melanoma tumors. In melanoma's localized stage of growth, it can be surgically removed, causing 92% of patients to go into remission. However, once this cancer enters the red blood vessels and lymph nodes and metastasizes throughout the body, the survival rate decreases to 17%. Because of this, early detection and the removal of cancerous growth is essential (American Cancer Society,…
There are 3 major skin cancers; melanoma, basal cell, and squamous cell cancer. Melanoma begins in the melanocytes and occurs mostly in people with fair skin, red or blonde hair, or blue or green eyes. Melanoma can form on any part of the body but usually occurs on the skin of the head, neck, shoulders, and hips of men and is often found on the lower legs, shoulders, and hips of women. Melanoma rarely forms in people with dark skin, but in cases where it has it is most commonly found on the…
Common symptoms of melanoma include, the appearances of unusual moles on your body, painful itches, irregular sores, etc… Melanoma at times is hard to catch because people don’t normally keep track of the moles on their body. It’s rather difficult especially depending on their locations. Melanoma usually starts as a regular mole but later slowly starts to change and cause much discomfort. If a mole has developed a different skin shade or, if the surface of the mole has changed, it’s a sign that that person could have melanoma. it is advised by many professionals that people should constantly keep track of every spot they have throughout their…
In the last main type of skin cancer melanoma which is more dangerous, can spread, and appears where sunlight doesn't reach had larger brownish spots with darker speckles, moles that change in color, size or feels or bleeds, dark lesions on palms,…