Tabernanthe Iboga Research Paper

Iboga Tabernanthe Iboga: an unassuming shrub found in western Central African that bears white flowers and yellow fruit. Ingest a small amount and you'd get a pleasant stimulating aphrodisiac effect, ingest significantly more, and you'd be sent on a visionary trip described as more intense than any other psychedelic known to man. The Bwiti cult in Africa has been using Iboga as the central practice of their religion for hundreds and thousands of years. Ibogaine is the tryptamine molecule that is primarily responsible for Iboga's effect. Ibogaine similar to serotonin, but with a methyl molecule where the hydroxy group would be, and a more complex toluene structure with an ethyl group coming off. Ibogaine acts on almost all receptors in the brain, but primarily the …show more content…
Noribogaine is identical to ibogaine except for the demethylation of the 5 position on the tryptamine base. Noribogaine is more potent than Ibogaine and is estimated to account for most of Iboga’s effects. The partial agonism of the serotonergic system, as found with Lysergic Acid Diethylamide and Psilocybin Mushrooms, along with the partial agonism of the kappa and mu opioid receptors, as found in the dissociative hallucinogen Salvia Divinorum, leads to what is considered to be the most immersive visionary experience of any substance. This is most likely due to the synesthesia and visions caused by the serotonin system in tandem with the dissociation caused by the opioid receptors; making Iboga almost a cross section between LSD and Salvia. To add to this, Ibogaine and Noribogaine are both serotonin reuptake inhibitors which would intensify the trip even more due to further saturation of the serotonin receptors. Fortunately, the ratio of the lethal dose to the effective dose is 13 meaning that at a standard flood (full experience) dose Iboga has little potential for death. The pharmacology of Iboga goes beyond the