STIMULATORY AND INHIBITORY KILLER IMMUNOGLOBULIN-LIKE RECEPTORS IN NATURAL KILLER T (NKT) CELLS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHROMATOSIS: RELATION TO DISEASE ACTIVITY
By
Aya Mohammed Ibrahim Askar
INTRODUCTION Systemic lupus is a chronic autoimmune disease with a wide variable manifestations that affect almost any organ systems (i.e. skin, joints, kidney, and nervous system) .
The diagnosis of SLE is depend on a combination of laboratory evidences and clinical data. The presence of criteria of SLE diagnosis yields specificity of 95% and sensitivity of 85% in SLE diagnosis. Accordingly, person is classified to have SLE based on the presence of a proven lupus nephritis with biopsy and positive anti-dsDNA or ANA antibodies have been satisfied. …show more content…
The innate immune system is important for non-inflammatory removal of apoptotic material result in response to cell aging. The formed antibodies, other acute-phase proteins clear the result of cell death by opsonization. Abnormal factors function predispose to autoimmune disease to develop.
One of T cells types is NKT cells that share the surface markers of both NK cells (CD56+ and/or CD161+ expression) and T cells (CD3+ expression).
Some studies have shown that SLE was associated with an emergence of auto-reactive T cells and a reduction in regulatory T cells. NKT cells consider a part of T regularity cells network that inhibits the induction of SLE.
Additionally, SLE patients and other autoimmune illnesses have shown a recovery in their decrease count of NKT cells with the improvement SLE disease activity, suggesting a function of these cells in the regulation of
By
Aya Mohammed Ibrahim Askar
INTRODUCTION Systemic lupus is a chronic autoimmune disease with a wide variable manifestations that affect almost any organ systems (i.e. skin, joints, kidney, and nervous system) .
The diagnosis of SLE is depend on a combination of laboratory evidences and clinical data. The presence of criteria of SLE diagnosis yields specificity of 95% and sensitivity of 85% in SLE diagnosis. Accordingly, person is classified to have SLE based on the presence of a proven lupus nephritis with biopsy and positive anti-dsDNA or ANA antibodies have been satisfied. …show more content…
The innate immune system is important for non-inflammatory removal of apoptotic material result in response to cell aging. The formed antibodies, other acute-phase proteins clear the result of cell death by opsonization. Abnormal factors function predispose to autoimmune disease to develop.
One of T cells types is NKT cells that share the surface markers of both NK cells (CD56+ and/or CD161+ expression) and T cells (CD3+ expression).
Some studies have shown that SLE was associated with an emergence of auto-reactive T cells and a reduction in regulatory T cells. NKT cells consider a part of T regularity cells network that inhibits the induction of SLE.
Additionally, SLE patients and other autoimmune illnesses have shown a recovery in their decrease count of NKT cells with the improvement SLE disease activity, suggesting a function of these cells in the regulation of