Mathematically Modelling Clinical Resolutions of CSF pressure in Type-I Chiari Malformation and Syringomyelia Patients.
Alexander S. Iacobucci, Andrew A. Hassall, Meagan E. Harrington, Korey V. Scanlin
Introduction: Type-I Chiari Malformation is a neurological disorder describing the herniation of the cerebellum past the foramen magnum, occasionally resulting in a condition known as Syringomyelia. This disorder causes cysts, known as syrinxes, to form in the spinal cord and result in severe damage to neurological function. In order to gain further insight into the resolution of this complex disorder, a simplified algebraic model can be constructed to represent the interrupted flow of cerebrospinal fluid. One of the greatest obstacles for …show more content…
The present model is being generated in order to produce an even further simplified, algebraic model to represent the flow of CSF fluid in Type-1 Chiari Malformation patients presenting Syringomyelia. This mathematical model is to be created through the combination of well-documented equations, as well as the simplification/elimination of unnecessarily complicated parameters and equations. The parameter values to be inserted will be obtained from previous studies done on CM patients. These methods will be applied in order to develop the discussed simplified algebraic model. The amalgamation of various models related to CSF flow will enable the elimination of certain limitations presented in each work. For example, the model presented by Elliott [1] incorporates the multisegmented system and provides a fairly useful, yet unrealistic, …show more content…
The algebraic model would enable surgeons to implement our simplified model into their practice, in order to identify specific procedures to resume normal CSF flow. The current prognosis for Syringomyelia within Type-I Chiari Malformation patients is quite positive, yet it is believed the methodology of surgical treatment can be improved through the application of the developed algebraic model. Continuation of the development of mathematical models representing the flow of CSF in Syringomyelia may produce publishable content. Considering the existing research available to implement within our experiment, the models available will facilitate the construction of novel equations illustrating Syringomyelia. One precautionary measure to observe is the prior research performed on this subject of interest. Due to the existing models found, the desired level of simplification may not be possible, and a change in direction may be required. Fortunately, the current goal is to develop a set of equations applicable to all disorders resulting in Syringomyelia, producing a universally applicable model. The pressing question that must be answered is whether or not this lofty goal is achievable. If no substance is produced, the group’s efforts can be redirected to intracranial pressure research topics, due to the present
Alexander S. Iacobucci, Andrew A. Hassall, Meagan E. Harrington, Korey V. Scanlin
Introduction: Type-I Chiari Malformation is a neurological disorder describing the herniation of the cerebellum past the foramen magnum, occasionally resulting in a condition known as Syringomyelia. This disorder causes cysts, known as syrinxes, to form in the spinal cord and result in severe damage to neurological function. In order to gain further insight into the resolution of this complex disorder, a simplified algebraic model can be constructed to represent the interrupted flow of cerebrospinal fluid. One of the greatest obstacles for …show more content…
The present model is being generated in order to produce an even further simplified, algebraic model to represent the flow of CSF fluid in Type-1 Chiari Malformation patients presenting Syringomyelia. This mathematical model is to be created through the combination of well-documented equations, as well as the simplification/elimination of unnecessarily complicated parameters and equations. The parameter values to be inserted will be obtained from previous studies done on CM patients. These methods will be applied in order to develop the discussed simplified algebraic model. The amalgamation of various models related to CSF flow will enable the elimination of certain limitations presented in each work. For example, the model presented by Elliott [1] incorporates the multisegmented system and provides a fairly useful, yet unrealistic, …show more content…
The algebraic model would enable surgeons to implement our simplified model into their practice, in order to identify specific procedures to resume normal CSF flow. The current prognosis for Syringomyelia within Type-I Chiari Malformation patients is quite positive, yet it is believed the methodology of surgical treatment can be improved through the application of the developed algebraic model. Continuation of the development of mathematical models representing the flow of CSF in Syringomyelia may produce publishable content. Considering the existing research available to implement within our experiment, the models available will facilitate the construction of novel equations illustrating Syringomyelia. One precautionary measure to observe is the prior research performed on this subject of interest. Due to the existing models found, the desired level of simplification may not be possible, and a change in direction may be required. Fortunately, the current goal is to develop a set of equations applicable to all disorders resulting in Syringomyelia, producing a universally applicable model. The pressing question that must be answered is whether or not this lofty goal is achievable. If no substance is produced, the group’s efforts can be redirected to intracranial pressure research topics, due to the present