Summary: The Innate Immune System

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Register to read the introduction… The system produces a number of substances include cationic antimicrobial peptides (CAMPs) such as defensins, bacteriolytic enzymes such as lysozyme etc. The production of these substances ensures that the microorganisms are destroyed before they get an opportunity to cause infections [4]. However, S. aureus has developed mechanisms, which enhance the evasion of the host immune system. The host’s body produces effector proteins after microbial invasion; nevertheless, S. aureus produces molecules that inhibit these proteins. Another mechanism used by the microbe involves binding of immune regulators produced by the host through the production of surface-bound molecules [5, 6]. Host cells produce Antimicrobial Peptides (AMPs) that help in exert cytotoxic activity on microorganisms. The capacity of S. aureus to counteract the activity of the AMPs is another mechanism that enables it to evade the immune system. The microbe has the ability to inhibit the cytotoxic effect through the alteration of the AMP by production of staphylokinase [4]. Neutrophil-mediated processes and phagocytosis are crucial in the host innate immune system. S. aureus has the ability to evade these systems and cause infections in the host and the processes involve many secreted and cell-surface-associated proteins [7]. The ability of the organism to resist antibiotics is another mechanism

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