There was no distinct or signifigant build up leading to the creation of vaccinations. Rather, it was documented that the first vaccination was created in 1790s when an English doctor named Edward jenner discovered that milk maids working in close proximity to cows were immune to the smallpox disease. He made a connection between these poeple being exposed to the cowpox disease and, in turn, being immune to the much more servere smallpox disease. After some observation and experimentation, Jenner injected an eight year old boy with the cowpox disease and two months later, he gave the boy the smallpox and proved his hypothesis when the boy experienced no illness. His assertion “that the cow-pox protects the human constitution from the infection
