Joseph Brillinger - 101012500
BIOL 1010 ‐ Biotechnology and Society
Assignment #1
The Carleton Prize for Biotechnology Robert W. Holley, H. Gobind Khorana, Marshall W. Nirenberg for winning the Nobel Prize in physiology or Medicine in 1968. They received this award for their interpretation of the genetic code, and its function in protein synthesis.
Joseph Brillinger – 101012500
Khorana, Nirenberg and Holley won the 1968 Nobel Prize in Physiology or Medicine for their interpretation of the genetic code and its function in protein synthesis. In 1953 James Watson and Francis Crick revealed the structure and properties of deoxyribonucleic acid (DNA) to be made of nucleic acids arranged in a double helix. …show more content…
Matthaei. They accomplished this in a series of experiments called ‘cell-free. In this experiment, all the things needed for protein synthesis were added to make a very simple nucleic acid in a test tube. They composed a chain of only one single repeated letter: the nucleotide uracil (UUU). Nirenberg and Matthaei’s experiment was successful in showing that that the template for the amino acid phenylalanine was composed of a strand of U triplets and thereby cracked the first letter of the code (Fredholm, 2004). The pair later discovered that CCC was the template for the amino acid proline.
Har Gobind Khorana also played a crucial role in understanding the composition of the genetic code. He “devised precise and intricate biochemical methods to produce well-defined nucleic acids, long strands of RNA with every nucleotide in exact position. The first one he made was a strand repeating the two nucleotides UCUCUC. This translated into a strand of amino acids, reading serine-leucine-serine-leucine...” (Fredholm, 2004). Synthetic RNA were later used to decipher the rest of the genetic …show more content…
With the genetic code now cracked, further advancements in molecular biology and biotechnology could now take place. The genetic code is universal so at the basic level it operates the same way throughout biology. It is used by cells in humans, plants, bacteria and all other species (Thieman & Palladino, 2004). Understanding genetics leads to a whole new array of tools and techniques in biotechnology. For this reason I feel that Nirenberg, Khorana and Holley’s work with the genetic code and protein synthesis deserves the Carleton prize for Biotechnology. The combined effort of all three members creates a comprehensive understanding of DNA, establishing a solid foundation for future developments in
BIOL 1010 ‐ Biotechnology and Society
Assignment #1
The Carleton Prize for Biotechnology Robert W. Holley, H. Gobind Khorana, Marshall W. Nirenberg for winning the Nobel Prize in physiology or Medicine in 1968. They received this award for their interpretation of the genetic code, and its function in protein synthesis.
Joseph Brillinger – 101012500
Khorana, Nirenberg and Holley won the 1968 Nobel Prize in Physiology or Medicine for their interpretation of the genetic code and its function in protein synthesis. In 1953 James Watson and Francis Crick revealed the structure and properties of deoxyribonucleic acid (DNA) to be made of nucleic acids arranged in a double helix. …show more content…
Matthaei. They accomplished this in a series of experiments called ‘cell-free. In this experiment, all the things needed for protein synthesis were added to make a very simple nucleic acid in a test tube. They composed a chain of only one single repeated letter: the nucleotide uracil (UUU). Nirenberg and Matthaei’s experiment was successful in showing that that the template for the amino acid phenylalanine was composed of a strand of U triplets and thereby cracked the first letter of the code (Fredholm, 2004). The pair later discovered that CCC was the template for the amino acid proline.
Har Gobind Khorana also played a crucial role in understanding the composition of the genetic code. He “devised precise and intricate biochemical methods to produce well-defined nucleic acids, long strands of RNA with every nucleotide in exact position. The first one he made was a strand repeating the two nucleotides UCUCUC. This translated into a strand of amino acids, reading serine-leucine-serine-leucine...” (Fredholm, 2004). Synthetic RNA were later used to decipher the rest of the genetic …show more content…
With the genetic code now cracked, further advancements in molecular biology and biotechnology could now take place. The genetic code is universal so at the basic level it operates the same way throughout biology. It is used by cells in humans, plants, bacteria and all other species (Thieman & Palladino, 2004). Understanding genetics leads to a whole new array of tools and techniques in biotechnology. For this reason I feel that Nirenberg, Khorana and Holley’s work with the genetic code and protein synthesis deserves the Carleton prize for Biotechnology. The combined effort of all three members creates a comprehensive understanding of DNA, establishing a solid foundation for future developments in