Nephrotoxic Nephropathy
Definition: Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances both toxic chemicals and medications on renal function. There are various forms of nephrotoxicity. Some drugs may affect renal function in more than one way. Additionally, nephrotoxins are substances that display nephrotoxicity.
Nephrotoxicity is a significant adverse effect of the calcineurin inhibitors, cyclosporine, and tacrolimus. Nephrotoxicity can be divided into acute and chronic effects. Acute nephrotoxicity typically manifest as a rise in the serum creatinine, hyperkalemia and a decrease in urine output, particularly when cyclosporine or tacrolimus levels are above the normal therapeutic range.
Clinical Features: …show more content…
Long term calcineurin inhibitor use can result in cellular changes such as arteriolar hyalinosis, ischemic glomerulosclerosis, and interstitial fibrosis. Chronic allograft nephropathy is the result of incremental and cumulative damage to the nephrons and it is the leading cause of kidney transplant failure. Another cause of nephropathy is contrast-induced nephropathy. It is defined as the impairment of renal function and it is measured as either 25.1mg/dl in serum creatinine from the baseline or 0.5 mg/dl increase in absolute value within 48-72 hours of intravenous contrast …show more content…
Some of the complications of contrast-induced nephropathy are cardiac arrest, pulmonary embolism, acute respiratory distress syndrome, shock, and stroke. Some of the complications of drug-induced nephropathy are chronic interstitial nephritis, rhabdomyolysis, and glomerulonephritis.
Health Education: Instruct the patient to consult a doctor if there is blood in the urine, persistent swelling in the legs and ankles or increased blood pressure. Patients with Contrast-induced nephropathy should be educated about the necessity of follow-up care with their physicians with post-procedure serum creatinine estimation, especially if the incident was done on an outpatient basis. Finally, as a nurse, giving good psychological support is very important because patients with this kind of disease may experience depression, emotional stress, lethargy, etc. Therefore, a nurse must encourage them to take proper treatment and follow-up with doctors. A nurse must also encourage them to maintain a healthy lifestyle as it is very
Definition: Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances both toxic chemicals and medications on renal function. There are various forms of nephrotoxicity. Some drugs may affect renal function in more than one way. Additionally, nephrotoxins are substances that display nephrotoxicity.
Nephrotoxicity is a significant adverse effect of the calcineurin inhibitors, cyclosporine, and tacrolimus. Nephrotoxicity can be divided into acute and chronic effects. Acute nephrotoxicity typically manifest as a rise in the serum creatinine, hyperkalemia and a decrease in urine output, particularly when cyclosporine or tacrolimus levels are above the normal therapeutic range.
Clinical Features: …show more content…
Long term calcineurin inhibitor use can result in cellular changes such as arteriolar hyalinosis, ischemic glomerulosclerosis, and interstitial fibrosis. Chronic allograft nephropathy is the result of incremental and cumulative damage to the nephrons and it is the leading cause of kidney transplant failure. Another cause of nephropathy is contrast-induced nephropathy. It is defined as the impairment of renal function and it is measured as either 25.1mg/dl in serum creatinine from the baseline or 0.5 mg/dl increase in absolute value within 48-72 hours of intravenous contrast …show more content…
Some of the complications of contrast-induced nephropathy are cardiac arrest, pulmonary embolism, acute respiratory distress syndrome, shock, and stroke. Some of the complications of drug-induced nephropathy are chronic interstitial nephritis, rhabdomyolysis, and glomerulonephritis.
Health Education: Instruct the patient to consult a doctor if there is blood in the urine, persistent swelling in the legs and ankles or increased blood pressure. Patients with Contrast-induced nephropathy should be educated about the necessity of follow-up care with their physicians with post-procedure serum creatinine estimation, especially if the incident was done on an outpatient basis. Finally, as a nurse, giving good psychological support is very important because patients with this kind of disease may experience depression, emotional stress, lethargy, etc. Therefore, a nurse must encourage them to take proper treatment and follow-up with doctors. A nurse must also encourage them to maintain a healthy lifestyle as it is very