Making ATP from Free fatty Acids:-
The other two energy substrates, FFAs and AAs, bypass glycolysis and ultimately enter the TCA cycle/oxidative phosphorylation as pyruvate, acetyl CoA, or different components of the TCA cycle. FFAs are released from adipose tissue by lipolysis and circulate in blood bound to serum albumin. Transport proteins then translocate FFAs into cells. FFAs are metabolized in mitochondria by the repetitive, cyclic process of β oxidation. This requires the transport of FFAs into the inner mitochondrial matrix by the carnitine palmitoyltransferase (CPT-I and CPT-II) system of transporters. Each cycle of β oxidation removes two carbon moieties at a time from FFA chains and generates a molecule of acetyl CoA, which is oxidized
The other two energy substrates, FFAs and AAs, bypass glycolysis and ultimately enter the TCA cycle/oxidative phosphorylation as pyruvate, acetyl CoA, or different components of the TCA cycle. FFAs are released from adipose tissue by lipolysis and circulate in blood bound to serum albumin. Transport proteins then translocate FFAs into cells. FFAs are metabolized in mitochondria by the repetitive, cyclic process of β oxidation. This requires the transport of FFAs into the inner mitochondrial matrix by the carnitine palmitoyltransferase (CPT-I and CPT-II) system of transporters. Each cycle of β oxidation removes two carbon moieties at a time from FFA chains and generates a molecule of acetyl CoA, which is oxidized