The heightened vulnerability of the brain to emotional and psychological insults during childhood likely results in long lasting changes in the brain that increase the risk of being afflicted by depression later in life43. Notably, understanding the link between childhood stress exposure and brain function can therefore provide critical insight into disease etiology44,45. Furthermore, a study on correlation between the early life stress and MDD in adulthood showed a striking correlation with reduction in hippocampal and PFC volumes46, which could signify an association between circuit and structural abnormalities. Can a faulty circuit lead to structural abnormalities? Perhaps they are independent defects that coexist under certain conditions resulting in higher levels of functional
The heightened vulnerability of the brain to emotional and psychological insults during childhood likely results in long lasting changes in the brain that increase the risk of being afflicted by depression later in life43. Notably, understanding the link between childhood stress exposure and brain function can therefore provide critical insight into disease etiology44,45. Furthermore, a study on correlation between the early life stress and MDD in adulthood showed a striking correlation with reduction in hippocampal and PFC volumes46, which could signify an association between circuit and structural abnormalities. Can a faulty circuit lead to structural abnormalities? Perhaps they are independent defects that coexist under certain conditions resulting in higher levels of functional