reduction in the hypertension. Canrenone is the active metabolite which is thought to play a significant part in exerting the pharmacological effects of the drug Spironolactone.
There are numerous side effects of Spironolactone, and some people even found that it had the potential to cause certain types of cancers as well, hence as a result questioning its safety. There are also other adverse effects of Spironolactone which involve the issue of severe hyperkalaemia, especially when Spironolactone is co-administered with other diuretics, non-steroidal anti-inflammatory drugs (NSAIDs) and other angiotensin-converting enzyme (ACE) inhibitors. (7) However, as James’ was not given NSAIDs along with Spironolactone, his chances of these adverse effects such as hyperkalaemia occuring are relatively low. In addition, Spironolactone is thought to be not effective at all because it acts by regulating aldosterone and Liddles’ syndrome does not respond to this regulation. As a result, drugs like Triamterene are found to be more effective and responsive to treating hypertension. …show more content…
Triamterene is responsible for inhibiting the epithelial sodium channels on the cells within the late distal convoluted tubule and the collecting tubules which are where sodium reabsorption takes place. (8)
When comparing Spironolactone and Triamterene, it is quite evident that Triamterene is most likely to be the best choice. Spironolactone effect once administered is delayed for about 24-48hours, due to the drug blocking the effects of aldosterone, which then is responsible for blocking the synthesis of proteins required for sodium and potassium transport. Whilst, on the other hand Triamterene, unlike Spironolactone is immediately well absorbed and the effects start taking place within 1 hour, or maximum 3hours.
There are numerous side effects of Spironolactone, and some people even found that it had the potential to cause certain types of cancers as well, hence as a result questioning its safety. There are also other adverse effects of Spironolactone which involve the issue of severe hyperkalaemia, especially when Spironolactone is co-administered with other diuretics, non-steroidal anti-inflammatory drugs (NSAIDs) and other angiotensin-converting enzyme (ACE) inhibitors. (7) However, as James’ was not given NSAIDs along with Spironolactone, his chances of these adverse effects such as hyperkalaemia occuring are relatively low. In addition, Spironolactone is thought to be not effective at all because it acts by regulating aldosterone and Liddles’ syndrome does not respond to this regulation. As a result, drugs like Triamterene are found to be more effective and responsive to treating hypertension. …show more content…
Triamterene is responsible for inhibiting the epithelial sodium channels on the cells within the late distal convoluted tubule and the collecting tubules which are where sodium reabsorption takes place. (8)
When comparing Spironolactone and Triamterene, it is quite evident that Triamterene is most likely to be the best choice. Spironolactone effect once administered is delayed for about 24-48hours, due to the drug blocking the effects of aldosterone, which then is responsible for blocking the synthesis of proteins required for sodium and potassium transport. Whilst, on the other hand Triamterene, unlike Spironolactone is immediately well absorbed and the effects start taking place within 1 hour, or maximum 3hours.