Sample Research Paper On Alzheimer's

Alzheimer’s disease is considered to be genetically heterogeneous, which means that the disease can be caused by a single mutation in a gene or multiple mutations in a gene. Early onset familial Alzheimer’s disease is an autosomal dominant disease, which means that there is enough of a mutation on one of the non-sex chromosomes to cause the disease. You can receive this from either parent, depending on which parent has the dominant gene, most likely the parent who has familial history of Alzheimer’s. There have been studies to try and figure out the mode of inheritance for late onset Alzheimer’s, however; there has yet to be a study to prove the inheritance. Alzheimer’s has been researched as to have an effect on the APOE e4 allele, and people who inherit a single copy of the allele are at an increased risk for developing Alzheimer’s. However, research shows that not everyone who has that allele develops Alzheimer’s.
Susceptible Genes …show more content…
If any of these three genes become altered they cause in increase release of toxins to the body and brain. Eventually, over time it will cause a build up in the brain which will lead to Alzheimer’s. The gene that is affected by Late Onset Alzheimer’s is the APOE e4 allele. People who develop the mutation in the APOE e4 allele are known to have developed Alzheimer’s at an earlier age than those who have the mutation in PSEN2 and APP. TREM2 allele is a very rare mutation that causes Alzheimer’s and has a very low occurrence rate, however; it has been researched and may also interact with the APOE allele to increase a person’s chance of developing the