Chronic diseases of respiratory system are the fourth leading cause of death in the United States. They affect airways and lung function, one common obstructive lung disease is asthma. According to CDC.gov about 17.8 million adults and 6.8 million children are suffering from asthma [9]. According to world health organization estimates, 235 million people suffer from asthma worldwide [10]. Asthma disease doesn’t have obvious symptoms which makes it hard to diagnose, so major component of chronic respiratory disease research is focused on identifying new diagnostic tool to help in early detection of asthma and other chronic respiratory disease.
In the past asthma has been known as a large airways disease, however recent studies show that small airways play an important role in asthma development[1]. The presence of inflammation in small airways has been well studied in previous research gaining a new insight on the contribution of the small airways to the clinical diagnostic for asthma[2]. There is increasing evidence that asthma disease starts by inflammation of small airways[3], therefore establishing significance of small airways disease is priority to advance asthma management [1, 4, 5]. Furthermore, studies on both children and …show more content…
It will be used to measure the change of respiratory system Impedance and phase over time to help detecting intermittent and mild pulmonary disease in early stages. This proposal has two hypotheses, first, the new developed portable device measures the respiratory impedance as accurate as the market devices. This is aim is designed to validate all the lab developed portable FOT devices. Second, the change in hourly temporal variation of respiratory system impedance and phase compared to normal values represents changes in lung mechanical function which is an indication of an early pulmonary
In the past asthma has been known as a large airways disease, however recent studies show that small airways play an important role in asthma development[1]. The presence of inflammation in small airways has been well studied in previous research gaining a new insight on the contribution of the small airways to the clinical diagnostic for asthma[2]. There is increasing evidence that asthma disease starts by inflammation of small airways[3], therefore establishing significance of small airways disease is priority to advance asthma management [1, 4, 5]. Furthermore, studies on both children and …show more content…
It will be used to measure the change of respiratory system Impedance and phase over time to help detecting intermittent and mild pulmonary disease in early stages. This proposal has two hypotheses, first, the new developed portable device measures the respiratory impedance as accurate as the market devices. This is aim is designed to validate all the lab developed portable FOT devices. Second, the change in hourly temporal variation of respiratory system impedance and phase compared to normal values represents changes in lung mechanical function which is an indication of an early pulmonary