In 1844, Chereau described sclera-cystic changes in human ovaries. In early 20th century , polycystic ovaries were thought to be the result of inflammation due to infection ,congestion due to pressure or partial torsion that disrupted normal blood flow to ovary or from dystrophy due to abnormalities in the ovarian nutrition. Androgen production of ovaries was not recognized till early 1900’s. The first case of a patient with glucose intolerance ,hirsuitism, and ovarian pathology was reported by Tuffier in 1914. In 1921, the French physician Achard and Thiers provided the first description of relationship androgen excess in women and carbohydrate metabolism, which was dubbed as “diabetic des femma a barbe” (diabetes of bearded
In 1844, Chereau described sclera-cystic changes in human ovaries. In early 20th century , polycystic ovaries were thought to be the result of inflammation due to infection ,congestion due to pressure or partial torsion that disrupted normal blood flow to ovary or from dystrophy due to abnormalities in the ovarian nutrition. Androgen production of ovaries was not recognized till early 1900’s. The first case of a patient with glucose intolerance ,hirsuitism, and ovarian pathology was reported by Tuffier in 1914. In 1921, the French physician Achard and Thiers provided the first description of relationship androgen excess in women and carbohydrate metabolism, which was dubbed as “diabetic des femma a barbe” (diabetes of bearded