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Polycystic Kidney Disease Research Paper

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Background: Polycystic Kidney Disease (PCKD) is the most frequent inherited renal cystic disease around the world. PCKD is a very complex group of disorders characterized by the formation and growth of multiple renal cysts, containing urine-like fluid, which displace renal tubules and frequently leads to end stage renal disease (ESRD). PCKD has two major forms and can be transmitted as autosomal dominant or recessive traits with variable expression. 1-3
Major advances have been done towards our understanding of the natural history, PCKD genetics, embryo- and cystogenesis, PCKD genes and proteins, intracellular signaling pathways and biomarkers. At the molecular, cellular and clinical level PCKD is associated with calcium dysregulation, …show more content…
Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007; 369:1287-1301
2. Grantham JJ. Clinical practice. Autosomal dominant polycystic kidney disease. N Engl J Med 2008;359: 1477-1485
3. Wilson P. Polycystic Kidney Disease, N Engl J Med 2004;352:151-164
4. Watson ML, Torres VE, ed: Polycystic kidney Disease. Oxford, UK, Oxford Medical Publications 1996..
5. Harris PC, Rosetti S. Molecular diagnosis for autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 2010;6:197-206
6. U.S. Renal Data System. United States Renal Data System 2012. Annual Data report. Volume One: Atlas of Chronic Kidney Disease. And Volume 2: End-Stage Renal Disease in the United States, Bethesda, M.D. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
7. Rayer P. Atlas in Traite des maladies des reins .Paris 1841,
8. Spithoven EM, Kramer A, Meijer E et al. Analysis of data from the ERA-EDTA Registry indicates that conventional treatments for chronic kidney disease do not reduce the need for renal replacement therapy in autosomal dominant polycystic kidney disease. Kidney International advance online publication 14 May

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