The poison oligomycin is an antibiotic that works a bit differently than the other poisons that interfere with cellular respiration. Instead of the electron transport chain being blocked as with cyanide and DNP, oligomycin blocks the protons in the enzyme during the ATP synthase process. This interferes with the phase 3 of cellular respiration. APT must be made in less efficient methods and more wasteful ways such fermentation. This can create a higher lactate acid build up in the cells which can cause many other problems for a person. Once this occurs, the process is not able to be reversed, so protons cannot cross back over the concentration gradient any longer.
