ABSTRACT
Alcoholism is a significant health problem in the world. The liver is the first and primary target organ for alcohol metabolism. Alcohol dehydrogenase and aldehyde dehydrogenase play important roles in the metabolism of alcohol and aldehyde. In this study, I aimed to investigate the eliminatory effects of a Phellinus spp on alcohol metabolism in drunken Sprague-Dawley (SD) rats. Male SD rats were given Phellinus spp extract at 30 min after 40% (5 g/kg) alcohol ingestion. To assay the effect of Phellinus spp extract on blood alcohol concentration, blood samples were taken from the tail vein at 1, 3 and 5 h after alcohol ingestion. The concentrations of alcohol, alcohol dehydrogenase, and aldehyde dehydrogenase in Phellinus spp extract …show more content…
Alcohol is a mild toxicant and its toxicity primarily comes from its metabolism. Abused alcohol is the main cause of liver disease worldwide and alcoholic liver disease is high ranked among the major causes of morbidity and mortality in the world (Smathers et al. 2011), and every year, it affects millions of people. The liver is the first and primary target organ for alcohol metabolism (Lieber 1988). But, other organs, including the kidneys, brain, and lungs, may also be affected by alcohol toxicity (Guidot and Roman 2002).
Alcohol is primarily catalyzed into acetaldehyde by alcoholic dehydrogenase (ADH) and cytochrome P4502E1, key enzymes in the microsomal ethanol oxidizing system. And then, acetaldehyde is transformed into acetic acid by mitochondrial and cytosolic acetaldehyde dehydrogenase (ALDH) isoenzymes (Klyosov et al. …show more content…
2010). Phellinus linteus (P. linteus), Phellinus gilvus (P. gilvus) and P. baumii are medicinal mushrooms belonging to the Hymenochaetaceae basidiomycetes family (Hwang et al. 2004), which is a source of many antitumor or immunostimulating polysaccharides and has been utilized in medicine for many human diseases in several Asian countries (including Korea) for a long time. A research regarding P. linteus demonstrates that it possesses antitumor(Kim et al. 2004), immunomodulating(Kim et al. 2004), antibacterial(Hur et al. 2004), antiangiogenic and antioxidant activity(Song et al. 2003). Furthermore, recent studies have shown that many other genera of Phellinus (e.g. P. baumii, P. gilvus and P. igniarius) also have potent pharmacological activities (Jang et al. 2004; Hwang et al. 2005; Lee et al. 2010). It also reported the anti-platelet (Kamruzzaman et al. 2011) and anti-inflammatory effects (Yayeh et al. 2012) of this mushroom extract; however, its protective effect against alcohol-induced liver diseases has never been investigated.
The aim of the current study was to investigate the protective effects of Phellinus spp extract on alcohol-induced hepatotoxicity in rats. To determine intake of Phellinus spp extract caused any liver damage, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also
Alcoholism is a significant health problem in the world. The liver is the first and primary target organ for alcohol metabolism. Alcohol dehydrogenase and aldehyde dehydrogenase play important roles in the metabolism of alcohol and aldehyde. In this study, I aimed to investigate the eliminatory effects of a Phellinus spp on alcohol metabolism in drunken Sprague-Dawley (SD) rats. Male SD rats were given Phellinus spp extract at 30 min after 40% (5 g/kg) alcohol ingestion. To assay the effect of Phellinus spp extract on blood alcohol concentration, blood samples were taken from the tail vein at 1, 3 and 5 h after alcohol ingestion. The concentrations of alcohol, alcohol dehydrogenase, and aldehyde dehydrogenase in Phellinus spp extract …show more content…
Alcohol is a mild toxicant and its toxicity primarily comes from its metabolism. Abused alcohol is the main cause of liver disease worldwide and alcoholic liver disease is high ranked among the major causes of morbidity and mortality in the world (Smathers et al. 2011), and every year, it affects millions of people. The liver is the first and primary target organ for alcohol metabolism (Lieber 1988). But, other organs, including the kidneys, brain, and lungs, may also be affected by alcohol toxicity (Guidot and Roman 2002).
Alcohol is primarily catalyzed into acetaldehyde by alcoholic dehydrogenase (ADH) and cytochrome P4502E1, key enzymes in the microsomal ethanol oxidizing system. And then, acetaldehyde is transformed into acetic acid by mitochondrial and cytosolic acetaldehyde dehydrogenase (ALDH) isoenzymes (Klyosov et al. …show more content…
2010). Phellinus linteus (P. linteus), Phellinus gilvus (P. gilvus) and P. baumii are medicinal mushrooms belonging to the Hymenochaetaceae basidiomycetes family (Hwang et al. 2004), which is a source of many antitumor or immunostimulating polysaccharides and has been utilized in medicine for many human diseases in several Asian countries (including Korea) for a long time. A research regarding P. linteus demonstrates that it possesses antitumor(Kim et al. 2004), immunomodulating(Kim et al. 2004), antibacterial(Hur et al. 2004), antiangiogenic and antioxidant activity(Song et al. 2003). Furthermore, recent studies have shown that many other genera of Phellinus (e.g. P. baumii, P. gilvus and P. igniarius) also have potent pharmacological activities (Jang et al. 2004; Hwang et al. 2005; Lee et al. 2010). It also reported the anti-platelet (Kamruzzaman et al. 2011) and anti-inflammatory effects (Yayeh et al. 2012) of this mushroom extract; however, its protective effect against alcohol-induced liver diseases has never been investigated.
The aim of the current study was to investigate the protective effects of Phellinus spp extract on alcohol-induced hepatotoxicity in rats. To determine intake of Phellinus spp extract caused any liver damage, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also