Peripheral giant cell granulomas (PGCG) are relatively uncommon reactive exophytic lesions of the oral cavity. Such a term is also synonymous to peripheral giant cell epulis, peripheral giant cell reparative granuloma though the word reparative granulomas is now considered obsolete in modern medicine because it’s not truly reparative.4,5
Clear aetiology of PGCG still remains elusive to and what is available currently are the laid hypothesis by various scholars for example local irritation from poor dental restorations, dental extraction, plaque, calculus accumulation and dental implant splay significant role in its development. A possible hormonal (Estrogen & progesterone) influence for some Peripheral Giant Cell Granuloma has been postulated …show more content…
The giant cells may contain only a few nuclei or up to several dozen and their pathogenesis has not been well studied. Abundant hemorrhage is characteristically found throughout the mass which often results in deposits of hemosiderin. Areas of reactive bone formation or dystrophic calcifications may be seen.2,7,11,13 The histopathology of the case presented tallies with this histopathological picture which has been reported from various literatures.
Traditional treatment of a PGCG consists of surgical resectioning of the lesion and elimination of the etiological factors. When the periodontal membrane is affected, full resectioning may require extraction of adjacent teeth. As an alternative to surgery, carbon-dioxide laser resectioning involves less intra-operative bleeding, provides wound sterilization and requires no sutures. However, laser treatment is contraindicated in cases where the lesion is oriented close to the bone and where careful curettage is required.7,10,11
No malignant variations of PGCGs have been reported, and recurrence rates have been reported to range from 4.41%– 50% with the differences in rates possibly related to the type of surgical resectioning procedure
Clear aetiology of PGCG still remains elusive to and what is available currently are the laid hypothesis by various scholars for example local irritation from poor dental restorations, dental extraction, plaque, calculus accumulation and dental implant splay significant role in its development. A possible hormonal (Estrogen & progesterone) influence for some Peripheral Giant Cell Granuloma has been postulated …show more content…
The giant cells may contain only a few nuclei or up to several dozen and their pathogenesis has not been well studied. Abundant hemorrhage is characteristically found throughout the mass which often results in deposits of hemosiderin. Areas of reactive bone formation or dystrophic calcifications may be seen.2,7,11,13 The histopathology of the case presented tallies with this histopathological picture which has been reported from various literatures.
Traditional treatment of a PGCG consists of surgical resectioning of the lesion and elimination of the etiological factors. When the periodontal membrane is affected, full resectioning may require extraction of adjacent teeth. As an alternative to surgery, carbon-dioxide laser resectioning involves less intra-operative bleeding, provides wound sterilization and requires no sutures. However, laser treatment is contraindicated in cases where the lesion is oriented close to the bone and where careful curettage is required.7,10,11
No malignant variations of PGCGs have been reported, and recurrence rates have been reported to range from 4.41%– 50% with the differences in rates possibly related to the type of surgical resectioning procedure