Periodontiits:
Periodontal disease is one of the most prevalent disease throughout the world (Albandar 2011). It is a chronic bacterial inflammatory infection leading to destruction of supporting tissues of teeth (Moffatt, Whitmore et al. 2011). It is second to dental caries as a cause of tooth loss among adults in developed countries (Gautam, Jindal et al. 2011), affecting 47.2% adults aged 30 years and older in the US (Eke, Dye et al. 2012).
Organisms causing periodontal diseases:
In a healthy mouth there are more than 350 species of microorganisms and periodontal infections are linked to less than 5% of these organisms (Haimov-Kochman, Kochman et al. 2004). For a number of years a small group of organisms, namely porphyromonas gingivalis, …show more content…
In streptococcus mutans, p.gingivalis and fusobacterium nucleatum, proteome analysis is used to understand the molecular mechanism of invasion, survival and pathogenesis. F.alocis ATCC 35896 and D-62D strain have variation in their protein profile. F.alocis genome has a total of 15 different proteases. These proteases may be membrane bound or extracellular. Among membrane bound proteases CaaX proteases are present in both the strains. In S.gordonii these proteases are known to play a role in protein transportion and protection of bacteria from bacteriocins. Protease HMPREF0389_00122 is present in the extracellular fraction of D-62D srain and this is known to have collagen peptidase function. This protease might be responsible for the damage of the connective tissue which leads to tissue destruction in periodontitis. So this could be important in f.alocis pathogenesis. Proteins that play an important role in the amino acid metabolism are seen in f.alocis . although it lacks some inherent amino acid synthesis pathways it could alternate through protein degradation with the help of these proteases and peptidases. Also f.alocis has proteins responsible for ornithine catabolism and urea breakdown. So we can say that f.alocis has a wee developed nitrogen assimilatory pathway that is needed for alternative mode of amino acid synthesis.so we can conclude that f.alocis has mechanisms to provide for its nutritional needs.Also f.alocis ATCC 35896 has a secretory system-ii pilus domain containing protein and proteins involved in type II secretory pathway like thpeIV pilus assembly protein and trigger factor. f.alocis D62-D also showed proteins involved in secretory pathway like fimbrial assembly protein and protein export membrane protein. One of the major virulence mechanism in bacteria is extracellular secretion of proteins. Several proteins known to be responsible for the virulence of other bacteria are seen in
Periodontal disease is one of the most prevalent disease throughout the world (Albandar 2011). It is a chronic bacterial inflammatory infection leading to destruction of supporting tissues of teeth (Moffatt, Whitmore et al. 2011). It is second to dental caries as a cause of tooth loss among adults in developed countries (Gautam, Jindal et al. 2011), affecting 47.2% adults aged 30 years and older in the US (Eke, Dye et al. 2012).
Organisms causing periodontal diseases:
In a healthy mouth there are more than 350 species of microorganisms and periodontal infections are linked to less than 5% of these organisms (Haimov-Kochman, Kochman et al. 2004). For a number of years a small group of organisms, namely porphyromonas gingivalis, …show more content…
In streptococcus mutans, p.gingivalis and fusobacterium nucleatum, proteome analysis is used to understand the molecular mechanism of invasion, survival and pathogenesis. F.alocis ATCC 35896 and D-62D strain have variation in their protein profile. F.alocis genome has a total of 15 different proteases. These proteases may be membrane bound or extracellular. Among membrane bound proteases CaaX proteases are present in both the strains. In S.gordonii these proteases are known to play a role in protein transportion and protection of bacteria from bacteriocins. Protease HMPREF0389_00122 is present in the extracellular fraction of D-62D srain and this is known to have collagen peptidase function. This protease might be responsible for the damage of the connective tissue which leads to tissue destruction in periodontitis. So this could be important in f.alocis pathogenesis. Proteins that play an important role in the amino acid metabolism are seen in f.alocis . although it lacks some inherent amino acid synthesis pathways it could alternate through protein degradation with the help of these proteases and peptidases. Also f.alocis has proteins responsible for ornithine catabolism and urea breakdown. So we can say that f.alocis has a wee developed nitrogen assimilatory pathway that is needed for alternative mode of amino acid synthesis.so we can conclude that f.alocis has mechanisms to provide for its nutritional needs.Also f.alocis ATCC 35896 has a secretory system-ii pilus domain containing protein and proteins involved in type II secretory pathway like thpeIV pilus assembly protein and trigger factor. f.alocis D62-D also showed proteins involved in secretory pathway like fimbrial assembly protein and protein export membrane protein. One of the major virulence mechanism in bacteria is extracellular secretion of proteins. Several proteins known to be responsible for the virulence of other bacteria are seen in