Penile cancer, which occurs predominantly in elderly men, becomes more common with age, reaching a peak incidence at 70 years.(1) Risk factors for penile cancer include human papilloma virus (HPV) infection, smoking, phimosis and poor hygiene, while neonatal circumcision has been described as protective. Penile cancer occurs almost exclusively in uncircumcised men, with a lifetime risk of one in 100,000 globally, compared to 0.1 in 100,000 in Israel, where the majority of men are circumcised.(2) .If circumcision is done shortly after birth, as is the Jewish custom, carcinoma of the penis develops very rarely. If the operation is delayed until the age of 10 years, as in some Moslem countries, carcinoma is more likely to develop.[60] Circumcision
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Among the neoplastic, benign includes 02(6.67%) cases, carcinoma in-situ – 3 (10%), and malignant cases include 25(83.33%). This depicts the higher incidence of neoplastic cases compared to the other. Of the malignant cases, invasive squamous cell carcinoma constitutes 24 cases (80%) and the other one was reported as verroucous carcinoma.
The Squamous cell carcinoma usually begins at the glans penis or in the prepuce and gradually extends to involve the entire glans, shaft and corpora. The lesion may present as an induration, a painless nodule, a wart-like growth, an ulceration, or an exophytic lesion. Subsequently, as the prepuce erodes, a foul odour and discharge from the lesion may occur.
In this study, the predominant location of SCC, in situ or invasive, was the glans 10(35.71%) , It was followed by the foreskin in 7(25% ) of the cases and both in 8 (28.57%) shaft of the penis 3 (10.71%). In the literature investigated, the glans was also the predominant region affected (48%), but at a proportion much lower than that found in our study, followed by the foreskin (21%), glans and foreskin (9%) and body of the penis (less than 2%). 5,20,21 In our series, most of the patients ignored the initial penile lesions and delayed seeking treatment until problems of ulcers,bloody discharge, obstructive urinary symptoms and symptomatic anaemia
Among the neoplastic, benign includes 02(6.67%) cases, carcinoma in-situ – 3 (10%), and malignant cases include 25(83.33%). This depicts the higher incidence of neoplastic cases compared to the other. Of the malignant cases, invasive squamous cell carcinoma constitutes 24 cases (80%) and the other one was reported as verroucous carcinoma.
The Squamous cell carcinoma usually begins at the glans penis or in the prepuce and gradually extends to involve the entire glans, shaft and corpora. The lesion may present as an induration, a painless nodule, a wart-like growth, an ulceration, or an exophytic lesion. Subsequently, as the prepuce erodes, a foul odour and discharge from the lesion may occur.
In this study, the predominant location of SCC, in situ or invasive, was the glans 10(35.71%) , It was followed by the foreskin in 7(25% ) of the cases and both in 8 (28.57%) shaft of the penis 3 (10.71%). In the literature investigated, the glans was also the predominant region affected (48%), but at a proportion much lower than that found in our study, followed by the foreskin (21%), glans and foreskin (9%) and body of the penis (less than 2%). 5,20,21 In our series, most of the patients ignored the initial penile lesions and delayed seeking treatment until problems of ulcers,bloody discharge, obstructive urinary symptoms and symptomatic anaemia