In 1999, the FDA issued a boxed caution and restrictive labeling for pemoline merchandise. Since then, the prescription charge has decreased by eighty%. At least thirteen cases of pemoline-associated liver failure ensuing in liver transplant or demise have been suggested (a charge of liver failure 10–25 instances more than inside the trendy population). One case of pemoline-related liver failure was stated after advent of the boxed caution. Since May 2005, sales and marketing of Cylert and all commonplace products have ceased within the
