Clinical Presentation of Paget's disease of bone
Symptoms of Paget's disease
Paget's disease often has no symptoms and many people don't know they have the condition. The most common symptom is bone pain, but may include joint pain and signs of a nerve being compressed or damaged.
Bone pain
Bone pain caused by Paget's disease has been described as a constant, dull pain deep within the affected part of the body. The pain is usually worse at night when the patients are lying down. The affected area may also feel warm. As Paget's disease progresses, patients may experience deformities in the affected bones, such as twisted or misshapen limbs, or scoliosis (curvature of the spine). Affected bones can sometimes break (fracture), particularly …show more content…
Hypercalcaemia
The abnormally rapid process of bone regeneration associated with Paget's disease can sometimes lead to a build-up of calcium in the blood. This is hypercalcaemia. Hypercalcaemia only occurs in people with Paget's disease who have been confined to bed after having an operation or a fracture. However, even in these circumstances hypercalcaemia is quite rare. Symptoms of hypercalcaemia include extreme tiredness, depression, drowsiness, constipation, bone pain (or worsening bone pain if already present) It's also relatively common for people with hypercalcaemia to develop kidney stones.
Heart failure
In severe cases of Paget's disease, the blood vessels inside the bones can become damaged. This means the heart has to work harder to pump blood around the body.
Sometimes the heart may no longer be able to pump enough blood around the body to meet demand. This is known as heart failure and is a very rare complication of Paget's disease. Symptoms of heart failure include breathlessness, extreme tiredness and weakness and
Symptoms of Paget's disease
Paget's disease often has no symptoms and many people don't know they have the condition. The most common symptom is bone pain, but may include joint pain and signs of a nerve being compressed or damaged.
Bone pain
Bone pain caused by Paget's disease has been described as a constant, dull pain deep within the affected part of the body. The pain is usually worse at night when the patients are lying down. The affected area may also feel warm. As Paget's disease progresses, patients may experience deformities in the affected bones, such as twisted or misshapen limbs, or scoliosis (curvature of the spine). Affected bones can sometimes break (fracture), particularly …show more content…
Hypercalcaemia
The abnormally rapid process of bone regeneration associated with Paget's disease can sometimes lead to a build-up of calcium in the blood. This is hypercalcaemia. Hypercalcaemia only occurs in people with Paget's disease who have been confined to bed after having an operation or a fracture. However, even in these circumstances hypercalcaemia is quite rare. Symptoms of hypercalcaemia include extreme tiredness, depression, drowsiness, constipation, bone pain (or worsening bone pain if already present) It's also relatively common for people with hypercalcaemia to develop kidney stones.
Heart failure
In severe cases of Paget's disease, the blood vessels inside the bones can become damaged. This means the heart has to work harder to pump blood around the body.
Sometimes the heart may no longer be able to pump enough blood around the body to meet demand. This is known as heart failure and is a very rare complication of Paget's disease. Symptoms of heart failure include breathlessness, extreme tiredness and weakness and